{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:36:53Z","timestamp":1777927013529,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T00:00:00Z","timestamp":1254268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T00:00:00Z","timestamp":1254268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Neonate"],"abstract":"<jats:p>Cocaine (1.5 mg\/kg i.v.) was administered to awake newborn piglets that were pretreated with either intravenous saline (placebo) or SCH23390, a dopamine antagonist, to study dopamine\u2019s role in cocaine\u2019s vascular and behavioral actions. In the placebo group, cocaine increased the locomotor activity and cerebellar and cardiac blood flow (31 \u00b1 36 and 72 \u00b1 66%), but decreased choroid plexus and renal blood flow (47 \u00b1 23 and 18 \u00b1 19%). In the SCH23390-treated group, cocaine did not affect organ blood flow or locomotor activity. Cocaine transiently increased the mean arterial blood pressure in both groups (10 \u00b1 7 and 18 \u00b1 13%). These data indicate that the behavioral and blood flow responses to cocaine in cerebellum, choroid plexus, heart, and kidneys are mediated by dopamine, whereas the arterial pressor response to cocaine is not.<\/jats:p>","DOI":"10.1159\/000244348","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T06:01:57Z","timestamp":1254463317000},"page":"52-59","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Dopamine Antagonism on the Behavioral and Hemodynamic Responses to Cocaine in Piglets"],"prefix":"10.1159","author":[{"given":"Constance L.","family":"Monitto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Feuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"O\u2019Rourke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,9,30]]},"container-title":["Biology of the Neonate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/244348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000244348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:32:30Z","timestamp":1777674750000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000244348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000244348","archive":["Portico"],"relation":{},"ISSN":["0006-3126","1421-9727"],"issn-type":[{"value":"0006-3126","type":"print"},{"value":"1421-9727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,30]]}}}