{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:52:13Z","timestamp":1777866733628,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T00:00:00Z","timestamp":1254787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T00:00:00Z","timestamp":1254787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Although ageing has been thought to be irreversible, studies made during the last decade have shown that a few topical compounds may limit or improve the age-related skin damages. The efficacy of tretinoin (all-trans-retinoic acid) in treating photoageing is well established. Identifying other compounds with similar effect and improved tolerance would be greatly valued. In this double-blind study, a new \u03b2-lipohydroxyacid compound was evaluated. To address a comparison between products, 6 volunteers completed a 4-week study using twice daily 0.025% tretinoin, 5% salicylic acid, 1.5% \u03b2-lipohydroxyacid or vehicle. Immunohistochemistry and computerized image analysis were performed on skin sections from biopsies taken after treatment. We searched for changes in epidermal renewal (Ki-67 labeling), modifications in cytokeratin (56\u201365 kD) and filaggrin patterns, and in tumor necrosis factor \u03b1 (TNF-\u03b1), Ulex europaeus and factor XIIIa expressivity. The vehicle- and salicylic-acid-treated areas had an aspect similar to untreated control sites. Both \u03b2-lipohydroxyacid and tretinoin induced enhanced epidermal proliferation and thickness with activation of factor XIIIa+ dendrocytes. The effects were more pronounced at the tretinoin-treated site. We speculate that TNF-\u03b1 might mediate some of the dermal effects. The \u03b2-lipohydroxyacid mimics some of the stimulatory effects of tretinoin on the epidermis and dermis. This new compound should be listed among topical products boosting the skin tissues affected by ageing.<\/jats:p>","DOI":"10.1159\/000246160","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T07:08:20Z","timestamp":1254899300000},"page":"398-401","source":"Crossref","is-referenced-by-count":17,"title":["Dermo-Epidermal Stimulation Elicited by a \u03b2-Lipohydroxyacid: A Comparison with Salicylic Acid and AII-Trans-Retinoic Acid"],"prefix":"10.1159","author":[{"given":"G.E.","family":"Pi\u00e9rard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Nikkels-Tassoudji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Arrese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pi\u00e9rard-Franchimont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"L\u00e9v\u00eaque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,10,6]]},"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/246160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000246160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:14:09Z","timestamp":1777540449000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000246160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000246160","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,6]]}}}