{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:31:44Z","timestamp":1775305904590,"version":"3.50.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Cathepsin D is the most abundant lysosomal and endosomal aspartyl protease; it shows beta and gamma secretase activity in vitro by cleaving the amyloid precursor protein into amyloid beta protein. In recent studies, cathepsin D was co-localized with PrP&lt;sup&gt;Sc&lt;\/sup&gt;, the disease-associated form of the prion disease, and abnormal expression of cathepsin D correlated with tissue damage in brains of sporadic Creutzfeldt-Jakob disease (CJD). &lt;i&gt;Objective:&lt;\/i&gt; To investigate whether a polymorphism at position 224, C224T, on exon 2 of the cathepsin D gene (&lt;i&gt;CTSD)&lt;\/i&gt; is associated with sporadic CJD in the Korean population. &lt;i&gt;Methods:&lt;\/i&gt; We compared the genotype and allele frequencies at this polymorphism site in 172 sporadic CJD patients with those in 197 healthy Koreans. &lt;i&gt;Results and Conclusion:&lt;\/i&gt; Our study does not show a significant difference in genotype (p = 0.901) and allele (p = 0.509) frequencies of &lt;i&gt;CTSD&lt;\/i&gt; C224T between sporadic CJD patients and normal controls. This was the first genetic association study of &lt;i&gt;CTSD &lt;\/i&gt;in a sporadic CJD population.<\/jats:p>","DOI":"10.1159\/000246343","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T05:54:47Z","timestamp":1255413287000},"page":"302-306","source":"Crossref","is-referenced-by-count":9,"title":["Genetic Association of a Cathepsin D Polymorphism and Sporadic Creutzfeldt-Jakob 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