{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:53:29Z","timestamp":1777866809130,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Background: Mycosis fungoides (MF) is histologically characterized by an accumulation of T lymphocytes (T cells) in both epidermis and dermis. However, the mechanism of the formation of Pautrier\u2019s microabscess or the maintenance of the epidermal T cells has not yet been clarified. Objective: The rate of proliferation of these T cells was investigated. Methods: The formalin-fixed, paraffin-embedded sections from 9 cases of patch\/plaque stage MF were immunostained with proliferating cell nuclear antigen (PCNA). Results: The PCNA-positive T cell nuclei were found both in the epidermis (including Pautrier\u2019s microabscesses) and dermis in all the specimens. The mean PCNA indices of the T cells were 20.2 \u00b1 10.6% (mean \u00b1 SD) within the epidermis and 16.8 \u00b1 6.5% in the dermis, which was not statistically significantly different (p &gt; 0.05). The ratio of the PCNA index between the epidermis and dermis was 1.3 \u00b1 0.6, which was not apparently correlated with the duration of the disease (8.4 \u00b1 5.1 years). Conclusion: These findings suggested that in situ proliferation might contribute to the epidermal T cell population resulting in the formation of Pautrier\u2019s microabscesses and an increase in dermal T cell volume during the course of the disease.<\/jats:p>","DOI":"10.1159\/000246878","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T07:08:20Z","timestamp":1254899300000},"page":"354-358","source":"Crossref","is-referenced-by-count":4,"title":["Proliferative Activity of Epidermal and Dermal T Lymphocytes in Mycosis fungoides"],"prefix":"10.1159","author":[{"given":"P.","family":"Tu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Miki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,10,7]]},"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/246878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000246878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:23:56Z","timestamp":1777541036000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000246878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000246878","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,7]]}}}