{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:53:26Z","timestamp":1792007606946,"version":"4.4.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Kathon is a biocide consisting of a mixture of two isothiazolinone derivatives (5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one) in an approximate ratio of 3:1 respectively, and with MgCl&lt;sub&gt;2&lt;\/sub&gt; and Mg(NO&lt;sub&gt;3&lt;\/sub&gt;)&lt;sub&gt;2&lt;\/sub&gt; present as stabilizers. The isothiazolinones are marketed under several brand names, and the concentration of the active ingredient varies according to their intended application. At a concentration of 3\u201315 ppm it shows activity against a wide spectrum of fungi, gram-positive and gram-negative bacteria. Contact allergy to it has been caused by cosmetics and also by products used in the pottery and various other industries. Recently we had the opportunity to observe 6 cases of occupational allergic contact dermatitis from an isothiazolinone mixture named Grotan TK 2 in a large textile industry producing nylon. An oil emulsion containing isothiazolinones is used in the spinning phase of the work cycle to prevent bacterial contamination that would damage yarn quality; furthermore, it helps to decrease the electrostatic charge that is produced by high speed at which the yarn moves and also to decrease the breakage possibility.<\/jats:p>","DOI":"10.1159\/000247217","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T09:50:36Z","timestamp":1256118636000},"page":"109-111","source":"Crossref","is-referenced-by-count":22,"title":["Occupational Dermatitis from Isothiazolinones in the Nylon Production"],"prefix":"10.1159","author":[{"given":"R.","family":"Valsecchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Leghissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Piazzolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cainelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Seghizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,10,7]]},"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/247217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000247217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:25:48Z","timestamp":1777541148000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000247217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000247217","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,7]]}}}