{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:56:16Z","timestamp":1777866976907,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatologica"],"abstract":"<jats:p>The time interval from starting continuous application of 2,4-dinitro-1-chlorobenzene (DNCB) epicutaneously until the appearance of an allergic contact reaction, i.e. \u2018contact allergy time\u2019 (CAT), was determined. In 34 patients initially 2.0% DNCB ointment was administered for 2 days, then 0.05% DNCB ointment was applied daily (group I). In 39 patients only the 0.05% DNCB preparation was used (group II). The median of DNCB\u2013CAT was 11.2 \u00b1 0.8 days in group I and 22.3 \u00b1 3.7 days in group II (p &lt; 0.01). In patients older than 55 years DNCB\u2013CAT was significantly longer than in younger patients. The medians of DNCB-CAT did not differ in male and female patients. In contrast to the conventional DNCB-sensitization procedures, the CAT method allows one to measure induction and elicitation phase quantitatively.<\/jats:p>","DOI":"10.1159\/000249735","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T10:20:24Z","timestamp":1256293224000},"page":"1-5","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the Immune Status in vivo by the 2,4-Dinitro-1-Chlorobenzene Contact Allergy Time (DNCB-CAT)"],"prefix":"10.1159","author":[{"given":"Bernhard","family":"Przybilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Burg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Thieme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,10,13]]},"container-title":["Dermatologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/249735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000249735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:39:53Z","timestamp":1777541993000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000249735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000249735","archive":["Portico"],"relation":{},"ISSN":["0011-9075","2571-7197"],"issn-type":[{"value":"0011-9075","type":"print"},{"value":"2571-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,13]]}}}