{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:38:23Z","timestamp":1785245903116,"version":"3.55.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; We determined the effects of age and sex on the blood pressure (BP) response to angiotensin II (Ang II) infusion and evaluated the potential mechanistic role of the thiazide-sensitive NaCl cotransporter (NCC) and the epithelial sodium channel (ENaC). &lt;i&gt;Methods:&lt;\/i&gt; Male and female mice (\u223c3 or 21 months of age) were infused with Ang II or control for 7 days. &lt;i&gt;Results:&lt;\/i&gt; Males had a greater BP response to Ang II, somewhat enhanced by aging. Mean systolic BPs (at 7 days) were (mm Hg): 161, 143, 172, and 157 in young male, young female, old male, and old female mice, respectively. Immunoblotting changes in the whole kidney that supported this BP profile included a 51 and 52% increase in NCC band density in the old females and old males (as compared to sex-respective controls) with Ang II infusion, while the young males and young females showed an increase of 40 and 0%, respectively. Young males also had a greater reduction in major bands of \u03b2- and \u03b3-ENaC, than did young female mice. The natriuretic response to hydrochlorothiazide supported an increase in activity of NCC with Ang II in aged mice only. &lt;i&gt;Conclusions:&lt;\/i&gt; Increased sensitivity to Ang II in aging and male mice may involve overactivity of NCC.<\/jats:p>","DOI":"10.1159\/000252776","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T13:50:36Z","timestamp":1256133036000},"page":"554-562","source":"Crossref","is-referenced-by-count":33,"title":["Sex and Age Result in Differential Regulation of the Renal Thiazide-Sensitive NaCl Cotransporter and the Epithelial Sodium Channel in Angiotensin II-Infused Mice"],"prefix":"10.1159","volume":"30","author":[{"given":"Swasti","family":"Tiwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahla","family":"Riazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerendra K. Madala","family":"Halagappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Ecelbarger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000066129.12106.E2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000013292.78621.FD"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpheart.00969.2004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1550-8579%2806%2980219-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI7840"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00075.2004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpcell.00486.2005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.24.14552"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00063.2004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod31.3.446"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod27.2.327"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-4580%2895%2900072-M"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI601"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001897"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy1001.092641"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00422.2005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F11.23.2829"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.6.3301"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:01:17Z","timestamp":1745442077000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000252776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000252776","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}