{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:06:03Z","timestamp":1761512763908,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>The epidemiology of acute viral hepatitis (AVH) is dynamic and affected by many factors including hygiene, socioeconomic status and vaccination coverage. A total of 4,302 cases of AVH were sequentially enrolled in this nationwide study between 1980 and 2008. Of the cases of AVH, acute hepatitis A (AHA) accounted for 1,583 (36.8%), acute hepatitis B (AHB) for 1,197 (27.8%), acute hepatitis C (AHC) for 359 (8.3%), and non-A, non-B and non-C (non-ABC) for 1,163 (27.0%). Between 1980 and 1995, the proportions of AHA, AHB, AHC and non-ABC were approximately 40, 25, 10 and 25%; between 1996 and 2003, they were approximately 30, 30, 10 and 30%, and this shifted to approximately 10, 40, 10 and 40% in the last 5 years. The number of AHB caused by genotype A, which is not indigenous to Japan, was 6.0% between 1991 and 1996 but has been markedly increasing since 2000, to reach 52% in 2008. Autochthonous acute hepatitis E (AHE) accounted for 10\u201315% of non-ABC hepatitis after 2002. The etiology of AVH in Japan has been drastically changing. A marked increase of AHB genotype A and constant occurrence of autochthonous AHE require attention, and necessary measures should be taken.<\/jats:p>","DOI":"10.1159\/000252788","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T11:45:38Z","timestamp":1262864738000},"page":"70-75","source":"Crossref","is-referenced-by-count":39,"title":["Dynamic Epidemiology of Acute Viral Hepatitis in Japan"],"prefix":"10.1159","volume":"53","author":[{"given":"Koji","family":"Yano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Tamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yatsuhashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsumasa","family":"Komori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigo","family":"Abiru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000127428"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa050855"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.21309"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hepres.2006.06.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.20411"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.20320"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-004-1400-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000071460"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.10239"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.02081-08"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fjhep.2001.27221"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2FMEG.0b013e3282f5195a"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1086%2F444396"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.20206"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9071%28199911%2959%3A3%3C297%3A%3AAID-JMV6%3E3.0.CO%3B2-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2169%2Finternalmedicine.42.1065"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-003-1359-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1006%2Fviro.2001.1017"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1086%2F378074"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.206.173"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS1386-6346%2803%2900009-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2003.12.026"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.20147"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2957%2Fkanzo.47.384"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.20364"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hepres.2006.08.002"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:01:21Z","timestamp":1745442081000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000252788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000252788","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"type":"print","value":"0300-5526"},{"type":"electronic","value":"1423-0100"}],"subject":[],"published":{"date-parts":[[2010]]}}}