{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:42:10Z","timestamp":1745469730194,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objective:<\/i> Our aim was to investigate the effect of 1-year treatment with raloxifene, a selective estrogen receptor modulator, on plasma lipid profiles in Japanese postmenopausal type 2 diabetic patients. <i>Subjects and Methods:<\/i> A total of 43 Japanese women with postmenopausal osteoporosis and type 2 diabetes with serum low-density lipoprotein cholesterol (LDL-C) <3.59 mmol\/l, serum triglyceride <1.68 mmol\/l and serum high-density lipoprotein cholesterol (HDL-C) >1.03 mmol\/l, who took 60 mg\/day of raloxifene for 12 months, were enrolled. For analysis, they were divided into 2 groups: nonhyperlipidemia (n = 23) and hyperlipidemia treated with statin (n = 20). <i>Results:<\/i> Raloxifene treatment significantly induced a mean reduction in serum LDL-C from 2.90 to 2.36 and 2.67 mmol\/l in the nonhyperlipidemia and statin-treated group, respectively. However, the reduction ratio of serum LDL-C showed a significant difference in the nonhyperlipidemia group (17%) compared to the statin-treated group (7%; p = 0.03). Although serum HDL-C showed an increase in both groups (from 1.45 to 1.58 vs. from 1.40 to 1.47 mmol\/l), the increase ratio of serum HDL-C was not significant between the two groups. Raloxifene administration showed 15% reduction in the nonhyperlipidemia group (p = 0.02) and 13% reduction in the statin-treated group (p = 0.02) of urinary N-telopeptide of type I collagen. No significant change in blood HbA<sub>1c<\/sub> was observed in either group. <i>Conclusion:<\/i> The administration of raloxifene to type 2 diabetic women showed favorable efficacy on serum lipid profiles, particularly in patients without statin treatment.<\/jats:p>","DOI":"10.1159\/000252838","type":"journal-article","created":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T08:56:21Z","timestamp":1260348981000},"page":"68-72","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Raloxifene on Serum Lipids for Type 2 Diabetic Menopausal Women with or without Statin Treatment"],"prefix":"10.1159","volume":"19","author":[{"given":"Mihoko","family":"Matsumura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Monden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Domeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Yanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiori","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kawagoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kikuo","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.1.32"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186%2F1475-2840-6-25"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0149-2918%2803%2980114-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-5491.2007.02165.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2006-925140"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fjbmr.5650110615"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.279.18.1445"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.71.20"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.metabol.2005.02.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F01443610410001685565"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa062462"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001980170011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2710.2006.00753.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.1.122"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.297.5.499"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:01:42Z","timestamp":1745442102000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000252838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,9]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000252838","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2009,12,9]]}}}