{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:48:51Z","timestamp":1761630531946,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Nail involvement is known as a common finding in psoriatic patients and represents a significant impact on patients\u2019 quality of life. The treatment of nail psoriasis is often challenging, and there is a need for new therapeutic options. Biologicals effective in the treatment of moderate to severe chronic plaque psoriasis may represent a new therapeutic modality for this disease. Adalimumab is a fully human IgG1 monoclonal antibody that binds to tumor necrosis factor \u03b1 with high affinity and specificity. &lt;i&gt;Observations:&lt;\/i&gt; We report two cases of rapid improvement in nail psoriasis under adalimumab monotherapy with maintained effectiveness despite intermittent treatment as well as long remission after therapy discontinuation. &lt;i&gt;Conclusion:&lt;\/i&gt; The marked improvement of our two cases indicates that adalimumab may also help ameliorate nail psoriasis and warrants further controlled studies to establish the effectiveness and therapeutic regimes.<\/jats:p>","DOI":"10.1159\/000252853","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T14:20:29Z","timestamp":1256307629000},"page":"353-356","source":"Crossref","is-referenced-by-count":13,"title":["Marked Improvement in Nail Psoriasis during Treatment with Adalimumab"],"prefix":"10.1159","volume":"219","author":[{"given":"N.","family":"Irla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Yawalkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000182250"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000202179"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.2000.00663.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2895%2990189-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2007.07.042"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2008.08686.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2007.09.010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2007.08315.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2006.01783.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.01.101"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:01:48Z","timestamp":1745442108000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000252853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000252853","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2009]]}}}