{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:50:52Z","timestamp":1778673052309,"version":"3.51.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Hepatitis B virus (HBV) infection is highly prevalent in China. To identify the genotypes of HBV in the southern Yunnan Province of China, full-length HBV genomes were extracted from 1 Dai and 4 Hani HBV carriers and linked with the pMD T-18 vector. For each patient, 3\u201310 clones were sequenced directly and a consensus sequence was created. Genotypic and serotypic analysis revealed 4 HBV\/B (2 B2 with adw2 and 2 new subgenotypes with ayw1) and 1 HBV\/C (C1 with adrq+) genotypes. The divergences of the entire genome sequences of the new subgenotype were 0\u20130.9% and 2.99\u20136.48% between other known HBV\/B. Divergences in other coding regions revealed that it was more similar to B3 and B4 in the precore\/core gene (2.02 and 2.09%, respectively), and similar to B3 and B5 in the preS1\/S2\/S gene (2.24 and 2.78%, respectively). Phylogenetic trees using the precore\/core and X genes both revealed a new clad separating from the major trunk of genotype B with a 99% bootstrap value. These results show that the 2 consensus isolates are a mosaic of B3\u2013B5, which we designated to subgenotype B6. Considering the geographical distances, the relationship between B6 and other HBV\/B subgenotypes (B3\u2013B5) and HBV evolution needs to be further studied.<\/jats:p>","DOI":"10.1159\/000252912","type":"journal-article","created":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T07:46:39Z","timestamp":1256715999000},"page":"340-346","source":"Crossref","is-referenced-by-count":9,"title":["Novel Hepatitis B Virus Subgenotype in the Southern Yunnan Province of China"],"prefix":"10.1159","volume":"52","author":[{"given":"Tao","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-mei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Lian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Min","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1099%2F0022-1317-69-10-2575"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1099%2Fvir.0.80922-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3201%2Feid1411.080437"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128%2FJVI.02556-07"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.virusres.2007.07.016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000080872"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128%2FJVI.78.14.7575-7581.2004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128%2FJVI.76.12.5985-5992.2002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-1702%2895%2900069-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1099%2Fvir.0.81525-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2899%2900471-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-0934%2899%2900039-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1099%2Fvir.0.80771-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3748%2Fwjg.14.5674"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2F25.24.4876"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fbib%2F5.2.150"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1099%2Fvir.0.80810-0"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/252912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:02:13Z","timestamp":1745442133000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000252912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000252912","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5120884","asserted-by":"subject"}]},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}