{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:48:43Z","timestamp":1779896923835,"version":"3.53.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T00:00:00Z","timestamp":1256860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T00:00:00Z","timestamp":1256860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Previous studies have shown a disrupted development of cerebral blood vessels at term-equivalent age in prematurely born infants. <i>Objective:<\/i> To assess the anatomy of the circle of Willis in preterm neonates (gestational age 25\u201331 weeks) at term-equivalent age and to evaluate the relation between anatomic variations and blood flow through the internal carotid arteries (ICAs) and basilar artery (BA). <i>Methods:<\/i> In 72 preterm neonates, flow measurements (ml\/min) were obtained with 2-D phase-contrast magnetic resonance angiography (MRA) at term-equivalent age. Time-of-flight MRA was used to assess the circle of Willis for a dominant A1 segment of the anterior cerebral artery or a fetal-type posterior cerebral artery. Differences in flow were assessed with ANOVA. <i>Results:<\/i> In our cohort, 53\/72 (74%) neonates showed a variant type of the circle of Willis. The flow in the ICA at the side of a dominant A1 segment (43.3 ml\/min) was significantly increased compared to the flow in the contralateral ICA (33.0 ml\/min; p = 0.009) and tended to be higher than in the ICA in children with a normal anterior anatomy (38.4 ml\/min; p = 0.1). The flow in the BA was highest in neonates with a normal configuration of the posterior part of the circle of Willis (32.6 ml\/min) compared to children with a unilateral (25.3 ml\/min; p = 0.002) or bilateral fetal-type posterior cerebral artery (18.6 ml\/min; p < 0.001). <i>Conclusion:<\/i> Preterm neonates show a high prevalence of variant types of the circle of Willis at term-equivalent age. A relation could be demonstrated between variations in the circle of Willis and the flow in the ICA and BA.<\/jats:p>","DOI":"10.1159\/000253754","type":"journal-article","created":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T13:33:43Z","timestamp":1256909623000},"page":"235-241","source":"Crossref","is-referenced-by-count":19,"title":["Anatomy of the Circle of Willis and Blood Flow in the Brain-Feeding Vasculature in Prematurely Born Infants"],"prefix":"10.1159","volume":"97","author":[{"given":"B.J.M.","family":"van Kooij","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hendrikse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.N.L.","family":"Benders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroimage.2006.05.051"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000254729.27386.05"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2897%2900078-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2351031799"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000094007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01654581"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-3019%2885%2990275-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000198880.28827.84"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0730-725X%2896%2900092-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.107.4.719"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.107.482471"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ultrasmedbio.2004.10.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1203%2F01.pdr.0000232785.00965.b3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000014072"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2879%2980373-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2886%2990528-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00602621"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrdd.10050"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.106.479311"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/253754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/253754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:10:56Z","timestamp":1745442656000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000253754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,30]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000253754","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,30]]}}}