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Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T00:00:00Z","timestamp":1257120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T00:00:00Z","timestamp":1257120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>The activation of ABL tyrosine kinase in BCR\/ABL-positive chronic myelogenous leukemia (CML) leads to a diversity of biological changes related to the pathogenesis of the disease. In CML patients, we determined the expression of growth factor independence-1 (Gfi1), a transcription repressor with weak oncogenic activity. Our data demonstrated that the Gfi1 mRNA level in both the mononuclear cells and purified CD34&lt;sup&gt;+&lt;\/sup&gt; cells from CML were significantly higher as measured by quantitative real-time PCR. Using flow cytometry and Western blot, we also showed that the Gfi1 protein content was increased in CML CD34&lt;sup&gt;+&lt;\/sup&gt; cells. The expression of Gfi1 was correlated with BCR\/ABL significantly. Gfi1 may be implicated in the pathogenesis of CML and can serve as a potential target for the management of the disease.<\/jats:p>","DOI":"10.1159\/000253856","type":"journal-article","created":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T13:33:43Z","timestamp":1256909623000},"page":"1-5","source":"Crossref","is-referenced-by-count":13,"title":["The Growth Factor Independence-1 (Gfi1) Is Overexpressed in Chronic Myelogenous Leukemia"],"prefix":"10.1159","volume":"123","author":[{"given":"Min","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2008-07-077958"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa062867"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fleu.2009.38"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-03-066936"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V99.10.3530"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V99.6.1928"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1202191"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20021417"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS1074-7613%2802%2900501-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fng831"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1170"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature02994"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.emboj.7600419"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12185-009-0286-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0804863106"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.25.23.10338-10351.2005"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/253856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/253856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:11:51Z","timestamp":1745442711000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000253856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,2]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000253856","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2009,11,2]]}}}