{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:28:26Z","timestamp":1765826906814,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the &lt;i&gt;TSC1&lt;\/i&gt; and &lt;i&gt;TSC2&lt;\/i&gt; genes. Previous studies have estimated the prevalence of TSC to be 1:8,000 to 1:30,000. The numbers of patients and the populations accessed in these studies are relatively small. The aim of this study is to evaluate the prevalence of TSC in Taiwan with a population of 23 million people. &lt;i&gt;Methods:&lt;\/i&gt; 95% of Taiwanese are enrolled in a single national health insurance database. This study uses this database to estimate the prevalence of TSC in a large Chinese population. &lt;i&gt;Results:&lt;\/i&gt; The prevalence of TSC in Taiwan is estimated at 1:95,136. There is no prevalence difference in rural or urban areas. The ages of the patients ranges from 3 months to 75 years, with a mean of 14 \u00b1 11 years. Prevalence by age is 1:14,608, 1:18,851, and 1:24,617 for ages &lt;6, 12, and 18 years, respectively. Only 15% of patients disclose a family history of TSC. The majority of cases (71.2%) are diagnosed in an outpatient visit by a pediatrician. &lt;i&gt;Conclusion:&lt;\/i&gt; The low prevalence of TSC in Taiwan might result from differences in penetrance, family planning, ethnic groups, and disease-modifying genes.<\/jats:p>","DOI":"10.1159\/000254569","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T11:08:48Z","timestamp":1257505728000},"page":"335-341","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence of Tuberous Sclerosis Complex in Taiwan: A National Population-Based Study"],"prefix":"10.1159","volume":"33","author":[{"given":"Chien-Hui","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Darling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2961279-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1086%2F316951"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086%2F302381"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2350-7-72"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1991.tb37754.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.26.1.28"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-9071.2004.00836.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080%2F09286580490514450"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mph.0000212983.51867.46"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.21.4.272"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-8749.1996.tb12086.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2978872-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1017%2FS0012162206001058"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/254569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/254569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:18:59Z","timestamp":1745443139000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000254569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000254569","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"type":"print","value":"0251-5350"},{"type":"electronic","value":"1423-0208"}],"subject":[],"published":{"date-parts":[[2009]]}}}