{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:32:54Z","timestamp":1780367574742,"version":"3.54.1"},"reference-count":34,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Chronic obstructive pulmonary disease (COPD) affects millions of people and has limited treatment options. Surgical treatments for severe COPD with emphysema are effective for highly selected patients. A minimally invasive method for treating emphysema could decrease morbidity and increase acceptance by patients. &lt;i&gt;Objective:&lt;\/i&gt; To study the safety and effectiveness of the IBV\u00ae Valve for the treatment of severe emphysema. &lt;i&gt;Methods:&lt;\/i&gt; A multicenter study treated 91 patients with severe obstruction, hyperinflation and upper lobe (UL)-predominant emphysema with 609 bronchial valves placed bilaterally into ULs. &lt;i&gt;Results:&lt;\/i&gt; Valves were placed in desired airways with 99.7% technical success and no migration or erosion. There were no procedure-related deaths and 30-day morbidity and mortality were 5.5 and 1.1%, respectively. Pneumothorax was the most frequent serious device-related complication and primarily occurred when all segments of a lobe, especially the left UL, were occluded. Highly significant health-related quality of life (HRQL) improvement (\u20138.2 \u00b1 16.2, mean \u00b1 SD change at 6 months) was observed. HRQL improvement was associated with a decreased volume (mean \u2013294 \u00b1 427 ml, p = 0.007) in the treated lobes without visible atelectasis. FEV&lt;sub&gt;1&lt;\/sub&gt;, exercise tests, and total lung volume were not changed but there was a proportional shift, a redirection of inspired volume to the untreated lobes. Combined with perfusion scan changes, this suggests that there is improved ventilation and perfusion matching in non-UL lung parenchyma. &lt;i&gt;Conclusion:&lt;\/i&gt; Bronchial valve treatment of emphysema has multiple mechanisms of action and acceptable safety, and significantly improves quality of life for the majority of patients.<\/jats:p>","DOI":"10.1159\/000259318","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T10:50:37Z","timestamp":1258541437000},"page":"222-233","source":"Crossref","is-referenced-by-count":102,"title":["A Multicenter Pilot Study of a Bronchial Valve for the Treatment of Severe 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