{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:23:44Z","timestamp":1759047824794,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Interleukin-1 is a potent proinflammatory cytokine involved in the pathophysiology of Alzheimer\u2019s disease (AD). We genotyped IL-1\u03b2 (\u2013511 C\/T) and the apolipoprotein E (APOE) common polymorphisms in a large case-controlled study in a Polish population. We included 332 patients with late-onset AD and 220 controls without any neurological deficit, cognitive complaints and history of neurological diseases, aged \u2265 65 years. The distribution of the IL-1\u03b2 (\u2013511 C\/T) genotypes was similar to that in the controls (AD: C\/C = 45.8%, C\/T = 44.6%, T\/T = 9.6% vs. controls: C\/C = 53.9%, C\/T = 38.3%, T\/T = 7.3%, p &gt; 0.05). Our study confirms previous reports that APOE \u03b54 is strongly related to the risk of AD (odds ratio = 6.60, 95% confidence interval 4.19\u201310.41). APOE status did not affect the distribution of the studied IL-1\u03b2 polymorphism. The IL-1\u03b2 (\u2013511 C\/T) polymorphism is not a risk factor for late-onset AD in a Polish population.<\/jats:p>","DOI":"10.1159\/000259460","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T08:28:15Z","timestamp":1259051295000},"page":"446-449","source":"Crossref","is-referenced-by-count":13,"title":["Interleukin-1 Gene \u2013511 CT Polymorphism and the Risk of Alzheimer\u2019s Disease in a Polish Population"],"prefix":"10.1159","volume":"28","author":[{"given":"A.","family":"Klimkowicz-Mrowiec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Marona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wo\u0142kow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Maruszak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Styczynska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Barcikowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zekanowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Szczudlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Slowik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2990.1998.00122.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0046-8177%2895%2990001-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2005.01.013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2803%2900011-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8249%28200003%2947%3A3%3C361%3A%3AAID-ANA12%3E3.0.CO%3B2-N"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8249%28200009%2948%3A3%3C388%3A%3AAID-ANA16%3E3.0.CO%3B2-G"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2005.01033.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8249%28200011%2948%3A5%3C817%3A%3AAID-ANA22%3E3.0.CO%3B2-S"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10196"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2004.04.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2008.02252.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000092845"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8249%28200005%2947%3A5%3C571%3A%3AAID-ANA3%3E3.0.CO%3B2-A"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainresrev.2008.07.003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2899%2900065-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.4652-05.2006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.10.6421"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000263217.36439.da"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0765.2000.035003172.x"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/259460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/259460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:22:05Z","timestamp":1745443325000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000259460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,12,1]]},"published-print":{"date-parts":[[2009,12,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000259460","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2009]]}}}