{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T20:13:27Z","timestamp":1772741607352,"version":"3.50.1"},"reference-count":49,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:00:00Z","timestamp":1258588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:00:00Z","timestamp":1258588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Addict Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the economic impact of buprenorphine\/naloxone (B\/N) as an agonist opioid treatment for opiate dependence. &lt;i&gt;Methods:&lt;\/i&gt; A budgetary impact analysis model was designed to calculate the annual costs (drugs and associated costs) to the Spanish National Healthcare System of methadone versus B\/N. Data for the model were obtained from official databases and expert panel opinion. &lt;i&gt;Results:&lt;\/i&gt; It was estimated that 86,017 patients would be in an agonist opioid treatment program each of the 3 years of the study. No increase in the number of patients is expected with the introduction of B\/N combination. The budgetary impact (drugs and associated costs) for agonist opiate treatment in the first year of the study would be 89.53 million EUR. In the first year of B\/N use, the budgetary impact would rise by 4.39 million EUR (4.6% of the total impact), with an incremental cost of 0.79 million EUR (0.9% of the total impact). The budgetary increase would be 0.6% (0.48 million EUR increase) and 0.6% (0.49 million EUR increase) in the second and third years of use, respectively. The mean cost per patient in the first year with and without B\/N would be EUR 1,050 and 1,041, respectively. The most influential variables in the sensitivity analysis were logistics and production costs of methadone and the percentage use of B\/N. &lt;i&gt;Conclusion:&lt;\/i&gt; With an additional cost of only EUR 9 per patient, B\/N is an efficient addition to the therapeutic arsenal in the drug treatment of opiate dependence, particularly when considering clinical aspects of novel pharmacotherapy.<\/jats:p>","DOI":"10.1159\/000259614","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T08:28:15Z","timestamp":1259051295000},"page":"31-42","source":"Crossref","is-referenced-by-count":8,"title":["Suboxone\u00ae (Buprenorphine\/Naloxone) as an Agonist Opioid Treatment in Spain: A Budgetary Impact Analysis"],"prefix":"10.1159","volume":"16","author":[{"given":"Jos\u00e9","family":"Mart\u00ednez-Raga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Gonz\u00e1lez 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