{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:32:29Z","timestamp":1770820349807,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T00:00:00Z","timestamp":1258761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T00:00:00Z","timestamp":1258761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; Patients with thalassemia major often present with a hypercoagulable state, the pathogenesis of which is still not understood. &lt;i&gt;Materials and Methods:&lt;\/i&gt; This study evaluates the risk factors for hypercoagulability in 50 \u03b2-thalassemia major patients and 50 healthy controls. Fasting total homocysteine, protein C (PC), protein S (PS), antithrombin (AT), activated protein C resistance (APCR) and lupus anticoagulant (LA) were assessed. MTHFR C677T mutation was determined. &lt;i&gt;Results:&lt;\/i&gt; Significant reductions in PC, PS and AT were noted in patients. Only 4% of the patients had hyperhomocysteinemia. Thirty-two percent of the patients were heterozygous and 4% were homozygous for MTHFR C677T mutation. &lt;i&gt;Conclusion:&lt;\/i&gt; The natural coagulation inhibitors PC, PS and AT were significantly reduced in patients with \u03b2-thalassemia major and were thus important risk factors for the hypercoagulable state, but hyperhomocysteinemia and MTHFR mutation do not seem to be significant risk factors for thromboembolic events.<\/jats:p>","DOI":"10.1159\/000260069","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T08:38:55Z","timestamp":1259051935000},"page":"37-42","source":"Crossref","is-referenced-by-count":12,"title":["Hypercoagulable State and Methylenetetra- hydrofolate Reductase (MTHFR) C677T Mutation in Patients with Beta-Thalassemia Major in Kuwait"],"prefix":"10.1159","volume":"123","author":[{"given":"Nada Y.","family":"Mustafa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajaa","family":"Marouf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Al-Humood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suad M.","family":"Al-Fadhli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusegun","family":"Mojiminiyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199907083410207"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000204216"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Ftropej%2F44.5.311"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-09-3167"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000039752"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V99.1.36"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000204720"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1999.01758.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0609.1998.tb01072.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.90.3.1004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cccn.2003.07.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11239-007-0163-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2003.026419"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/260069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/260069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:26:03Z","timestamp":1745443563000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000260069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,21]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000260069","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,21]]}}}