{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:43:26Z","timestamp":1745469806830,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. &lt;i&gt;Methods:&lt;\/i&gt; We performed a retrospective review by a blinded observer using the Lund-Mackay numerical scoring scale as well as a visual scale for remodeling changes in the paranasal sinus bone on CT scans in CVID patients. &lt;i&gt;Results:&lt;\/i&gt; The sinus CT scans of 19 subjects (9 males, 10 females; median age at diagnosis 34 years) are described. There was an inverse relationship between serum IgM and sinus mucosal thickening as described by the Lund-Mackay scale (R = \u20130.6398; p = 0.0032). Osteitis of the paranasal sinus bone was almost exclusively found in patients with a reduced serum IgM level of less than 25 mg\/dl (p = 0.0074). &lt;i&gt;Conclusion:&lt;\/i&gt; This is the first study to show that sinus mucosal thickening on CT in patients with CVID is inversely related to serum IgM levels.<\/jats:p>","DOI":"10.1159\/000260088","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T08:38:55Z","timestamp":1259051935000},"page":"81-86","source":"Crossref","is-referenced-by-count":5,"title":["Reduced Immunoglobulin M Is Associated with Sinus Mucosal Thickening, Osteitis and Sinus Surgery in Patients with Common Variable Immunodeficiency"],"prefix":"10.1159","volume":"152","author":[{"given":"John B.","family":"Hagan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Kita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert G.","family":"Campeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2876%2990173-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2008.02.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2961199-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006%2Fclim.1999.4725"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-11-124545"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10875-007-9075-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-06-091744"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed%2F95.10.655"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.88.12.1101"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2FRCT.0b013e31802e3c11"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200102000-00008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20022020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.10.048"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.06-2994"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1006%2Fclim.1999.4799"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2500%2Fajr.2006.20.2857"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.otohns.2004.09.067"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.otohns.2006.09.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2960216-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2007.04.011"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/260088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/260088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:26:20Z","timestamp":1745443580000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000260088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,24]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000260088","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2009,11,24]]}}}