{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:18:36Z","timestamp":1777771116132,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"abstract":"<jats:p>The effects of pre-eruptive and post-eruptive exposure to fluoride (F) administered in milk and in water were studied separately using Osborne-Mendel rats fed diet 2000 and infected by Streptococcus mutans 6715. In assessing pre-eruptive effects, two groups of animals received either milk or water containing F at a dose of 1 mg\/kg bodyweight by stomach tube from 5 to 15 days of age. Although these animals showed a significant increase in enamel uptake of F, their caries scores did not differ from those of untreated controls. In a second experiment, where post-eruptive effects were assessed, animals which drank 3 ml of milk or water containing 50 ppm F 5 days per week for 8 weeks also showed a significant increase in enamel F. The increase was slightly greater when the F was provided in milk than when it was in water. The post-eruptive administration of F resulted in significantly reduced levels of buccallingual caries but without effect on proximal or sulcal surfaces. There were no differences between the use of milk or water as the vehicle with respect to caries scores.<\/jats:p>","DOI":"10.1159\/000260204","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T06:08:16Z","timestamp":1258524496000},"page":"227-233","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Fluoridated Milk and Water on Enamel Fluoride Content and Dental Caries in the Rat"],"prefix":"10.1159","author":[{"given":"S.","family":"Poulsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.H.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,17]]},"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000260204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:45:28Z","timestamp":1777481128000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000260204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000260204","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,17]]}}}