{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:21:49Z","timestamp":1777771309030,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T00:00:00Z","timestamp":1258416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"abstract":"<jats:p>219 Osborne-Mendel rats were weaned at the age of 19 days, inoculated with Streptococcus mutans and fed a cariogenic diet for 42 days. The control group received no treatment; the 6 study groups received applications of Duraphat\u00ae, Fluor Protector\u00ae or a placebo varnish once daily on either days 19\u201321 or 25\u201327. Caries was significantly reduced by both fluoride varnishes. The effect was most pronounced on recently erupted teeth, on which the varnishes were equally effective. Duraphat was more effective than Fluor Protector when applied to more mature teeth. Varnish without fluoride did not prevent caries.<\/jats:p>","DOI":"10.1159\/000260636","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T06:08:16Z","timestamp":1258524496000},"page":"453-459","source":"Crossref","is-referenced-by-count":6,"title":["Caries Prevention by Two Fluoride Varnishes in Osborne-Mendel Rats"],"prefix":"10.1159","author":[{"given":"Liisa","family":"Sepp\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarit","family":"Koskinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Luoma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,17]]},"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000260636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:48:34Z","timestamp":1777481314000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000260636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000260636","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,17]]}}}