{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:15:58Z","timestamp":1782954958184,"version":"3.54.5"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The purpose of this study is to evaluate the level and pattern of cyclooxygenase-2 (Cox-2) expression in endometriosis and to investigate the correlation between the expression of Cox-2 and several clinicosurgical parameters. &lt;i&gt;Methods:&lt;\/i&gt; Twenty-six patients with endometriosis and 21 patients with other benign gynecological conditions were enrolled. The eutopic endometrium was sampled by pipelle, and fragments of ovarian endometrioma and non-endometriotic ovarian cysts were sampled during surgery. Total RNA isolation and semiquantitative reverse transcriptase polymerase chain reaction was performed. &lt;i&gt;Results:&lt;\/i&gt; The expression of Cox-2 mRNA (mean \u00b1 SEM) in eutopic endometrium and ovarian endometriotic tissue significantly increased in patients with endometriosis compared with the controls. The expression of Cox-2 increased significantly in the proliferative phase in eutopic endometrium and in the secretory phase in ovarian endometriotic tissue of patients with endometriosis compared with the controls. Cox-2 mRNA expression in the endometrium and ovarian lesions significantly correlated with serum CA-125 and the diameter of the endometrioma. &lt;i&gt;Conclusions:&lt;\/i&gt; Cox-2 expression increased in the eutopic endometrium and ovarian endometriotic tissue of the patients with endometriosis. These findings indicate that Cox-2 may be involved in the pathogenesis and progression of endometriosis.<\/jats:p>","DOI":"10.1159\/000261017","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T12:14:04Z","timestamp":1259151244000},"page":"93-100","source":"Crossref","is-referenced-by-count":37,"title":["Expression of Cyclooxygenase-2 in Eutopic Endometrium and Ovarian Endometriotic Tissue in Women with Severe Endometriosis"],"prefix":"10.1159","volume":"69","author":[{"given":"SiHyun","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hyeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sik","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Kyo","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Jae","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,11,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199306173282407"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0897.2003.00042.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1677%2Ferc.0.0060293"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.12.5765"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.2.600"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.271.52.33157"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00666095"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1281554"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F12.6.1300"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdmi034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F16.3.561"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeh054"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2004.03.059"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdei160"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fden315"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2897%2981391-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0897.2002.01101.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186%2F1477-7827-4-S1-S7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080%2F00016340500438173"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2007-1168"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2007.07.1332"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2008.01.070"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/261017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/261017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:36:04Z","timestamp":1745444164000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000261017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,25]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000261017","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,25]]}}}