{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:00:12Z","timestamp":1778166012963,"version":"3.51.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The pathogenesis of Alzheimer\u2019s disease (AD) is related to homocysteine (HC), but the details are unknown. &lt;i&gt;Objective:&lt;\/i&gt; We aimed to measure the cerebrospinal fluid (CSF) concentrations of 8-hydroxyguanosine (8-OHG), considering RNA oxidative damage marker, free HC and total HC in the CSF of patients with AD and in normal control subjects. &lt;i&gt;Method and Patients:&lt;\/i&gt; Subjects were 18 untreated patients with AD (M\/F = 7\/11) and 15 age-matched controls (M\/F = 9\/6), with a mean age \u00b1 SD of 67.4 \u00b1 5.0 years for patients and of 65.7 \u00b1 9.2 years for controls. The concentrations of free HC, total HC and 8-OHG in the CSF of AD patients were measured by high-performance liquid chromatography using an electrochemical detector. The control subjects were neurologically normal patients who underwent lumbar spinal anesthesia for minor surgery. &lt;i&gt;Results:&lt;\/i&gt; Total HC and 8-OHG concentrations were significantly increased, and there was a significant positive correlation between total HC and 8-OHG concentrations. However, the concentration of 8-OHG in the CSF showed no correlation with 8-OHG in serum and was not significantly altered in AD patients. &lt;i&gt;Conclusion:&lt;\/i&gt; These results suggest that total HC and 8-OHG are positively correlated and may be related to AD pathogenesis due to RNA-associated oxidative damage linked to total HC.<\/jats:p>","DOI":"10.1159\/000262443","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T21:31:39Z","timestamp":1259357499000},"page":"252-257","source":"Crossref","is-referenced-by-count":31,"title":["Homocysteine May Contribute to Pathogenesis of RNA Damage in Brains with Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"6","author":[{"given":"Chiaki","family":"Isobe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Terayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011613"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI112442"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI116712"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0595-111"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.270.22.2693"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000017092"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lfs.2005.02.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1373.1999.d01-140.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2899%2900406-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-5793%2887%2980305-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2894%2990131-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.10.5795"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0076-6879%2899%2909012-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.10349"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.1975.00490510088009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0076-6879%2894%2934073-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2801%2900327-X"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2001.00178.x"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/262443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/262443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:47:22Z","timestamp":1745444842000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000262443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":20,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2010,2,1]]},"published-print":{"date-parts":[[2010,2,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000262443","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}