{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:28:07Z","timestamp":1722940087454},"reference-count":17,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Laser Doppler flowmetry (LDF) is frequently used for non-invasive microvascular perfusion measurements. The aim of the present study was to analyze liver blood flow heterogeneity in detail using LDF devices under normal and low-flow conditions. <i>Materials and Methods:<\/i> In 5 anesthetized and laparotomized Suabian-Hall strain pigs, systemic hemodynamics and hepatic arterial\/portal venous blood flow were constantly recorded. Hepatic microcirculation was assessed by 2 different LDF devices, analyzing microvascular flow and velocity before, during and after inducing a Pringle\u2019s maneuver for hepatic inflow occlusion. Offline data analysis comprised differentiation between the two LDF devices used as well as calculation of temporal and spatial heterogeneity of liver perfusion. <i>Results:<\/i> Pringle\u2019s maneuver induced complete inflow occlusion, confirmed by hepatic arterial\/portal venous blood flow measurement. Laser Doppler signals showed a significant decrease during Pringle\u2019s maneuver. Spatial heterogeneity of flow and velocity increased more than temporal heterogeneity during Pringle\u2019s maneuver. <i>Conclusion:<\/i> Both LDF devices proved suitable for assessing hepatic microvascular perfusion during normal perfusion and low-flow conditions. Reduced microvascular perfusion induces a significant increase in temporal and spatial perfusion heterogeneity. In particular, the pronounced spatial heterogeneity requires measurements at different places when assessing hepatic microcirculation by LDF during impaired perfusion conditions.<\/jats:p>","DOI":"10.1159\/000264926","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T08:24:59Z","timestamp":1268123099000},"page":"152-158","source":"Crossref","is-referenced-by-count":3,"title":["Laser Doppler Flowmetry of Hepatic Microcirculation during Pringle\u2019s Maneuver: Determination of Spatial and Temporal Liver Tissue Perfusion Heterogeneity"],"prefix":"10.1159","volume":"44","author":[{"given":"S.","family":"Richter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kollmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Menger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.K.","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Chirurgische Arbeitsgemeinschaft OP-Technik und OP-Strukturen of the Deutsche Gesellschaft f\u00fcr Chirurgie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00006676-199907000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.45.3.341"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2893%2990179-O"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006%2Fmvre.2001.2353"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006%2Fmvre.1993.1025"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F02656739009141139"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fmvre.1994.1036"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000178947"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02347500"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002689900338"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-0270%2801%2900422-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006%2Fnimg.2001.0943"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000018632"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109%2F10739689509146756"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1076%2Fceyr.28.4.233.27830"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004240050826"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1088%2F0967-3334%2F21%2F2%2F312"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/264926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/264926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T06:19:11Z","timestamp":1716013151000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/ESR\/article\/doi\/10.1159\/000264926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":17,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2010,7,1]]},"published-print":{"date-parts":[[2010,7,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000264926","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2010]]}}}