{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T23:06:00Z","timestamp":1754262360524},"reference-count":15,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To locate fibroblast growth factor receptor (FGFRs) 1\u20134 in human chronic tympanic membrane (TM) perforation. &lt;i&gt;Methods:&lt;\/i&gt; A sample of human chronic TM perforation was harvested during myringoplasty. The sample was immediately fixed in 4% paraformaldehyde and embedded in OCT compound. Immunohistochemistry was performed with FGFR 1\u20134 polyclonal antibodies. &lt;i&gt;Results:&lt;\/i&gt; FGFRs 1\u20134 were strongly and weakly expressed in the epidermal and mucosal layer of the TM perforation, respectively. &lt;i&gt;Conclusions:&lt;\/i&gt; As it is impossible to perform quantitative analysis based on the fluorescence intensity of each immunoreactivity, the presence of FGFRs 1\u20134 in the human chronic TM perforation is shown. The expressions of FGFRs 1\u20134 indicated that the clinical use of bFGF agent is useful for myringoplasty.<\/jats:p>","DOI":"10.1159\/000265121","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T09:20:39Z","timestamp":1267435239000},"page":"67-70","source":"Crossref","is-referenced-by-count":3,"title":["Expression of Fibroblast Growth Factor Receptors 1\u20134 in Human Chronic Tympanic Membrane Perforation"],"prefix":"10.1159","volume":"71","author":[{"given":"Akinobu","family":"Kakigi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizo","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200308000-00016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.anl.2008.01.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fedrv-8-2-95"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.bi.58.070189.003043"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2885%2970213-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12874637"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0955-2235%2892%2990026-E"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0196-0709%2894%2990133-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109%2F08977199109000290"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02439709"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0194-5998%2899%2970122-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109%2F00016489109137397"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1288%2F00005537-199303000-00012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0194-5998%2896%2970008-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1677%2Ferc.0.0070165"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/265121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/265121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T22:53:25Z","timestamp":1726181605000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/ORL\/article\/doi\/10.1159\/000265121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":15,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000265121","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2009]]}}}