{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:11:37Z","timestamp":1777943497646,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T00:00:00Z","timestamp":1259884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T00:00:00Z","timestamp":1259884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"abstract":"<jats:p>Type-I hypersensitivity reactions were induced in guinea pigs by repeated topical\/conjunctival application of fluoresceinyl ovalbumin (FL-OA). The ocular reactivity in early responding animals was maximal between 16 and 25 days and decreased exponentially thereafter. Desensitized eyes responded minimally to compound 48\/80 but maximally to histamine. Unilateral sensitization and challenge with FL-OA produced desensitization of the immunized eye, but the reactivity of the contralateral eye persisted. A significant reduction in conjunctival stained mast cells was found in repeatedly challenged eyes. The desensitization therefore was due to a loss of reactive mast cells. Systemic infection with Ascaris suum, after repeated topical challenge with FL-OA had led to desensitization, produced a reappearance of type-I hypersensitivity reactions toward both FL-OA and ascarid antigens.<\/jats:p>","DOI":"10.1159\/000265365","type":"journal-article","created":{"date-parts":[[2009,12,7]],"date-time":"2009-12-07T12:10:25Z","timestamp":1260187825000},"page":"139-147","source":"Crossref","is-referenced-by-count":19,"title":["Induction and Down-Regulation of Conjunctival Type-I Hypersensitivity Reactions in Guinea Pigs Sensitized Topically with Fluoresceinyl Ovalbumin"],"prefix":"10.1159","volume":"17","author":[{"given":"Mahin","family":"Khatami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Rockey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,4]]},"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000265365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:27:13Z","timestamp":1777706833000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000265365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,4]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1985,3,1]]},"published-print":{"date-parts":[[1985,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000265365","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,4]]}}}