{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:08:41Z","timestamp":1776114521580,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Aims:<\/i> To evaluate health-related quality of life (HRQoL) in celiac disease (CD) patients at the time of diagnosis and during a gluten-free diet (GFD). <i>Patients and Methods:<\/i> We enrolled 43 adult CD patients (18 with a typical and 15 with an atypical clinical presentation, and 10 with dermatitis herpetiformis, DH) and 86 age- and sex-matched healthy controls. We administered the Short Form 36 Health Survey (SF-36) questionnaire at diagnosis and after 1, 12 and 24 months of a GFD. <i>Results:<\/i> At the time of diagnosis CD patients showed significantly lower SF-36 scores than controls; this figure was observed in women but not in men. At baseline, both typical and atypical CD patients had lower SF-36 scores than controls, while DH patients showed a SF-36 profile comparable to that of controls. During a GFD the SF-36 scores improved continuously in CD patients and in the female subgroup, becoming similar to those of matched controls at 1-year follow-up. After gluten withdrawal typical and atypical CD patients improved their SF-36 scores and reached values comparable to those of controls. <i>Conclusions:<\/i> At diagnosis, CD patients perceived a poor HRQoL; this figure appears to be mostly associated with female gender. In all subgroups of CD patients with a low HRQoL at diagnosis, the GFD allowed progressive restoration of HRQoL perception.<\/jats:p>","DOI":"10.1159\/000265549","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T07:14:21Z","timestamp":1277363661000},"page":"221-228","source":"Crossref","is-referenced-by-count":29,"title":["Impact of Gluten Withdrawal on Health-Related Quality of Life in Celiac Subjects: An Observational Case-Control Study"],"prefix":"10.1159","volume":"82","author":[{"given":"Gian Eugenio","family":"Tontini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Rondonotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Saladino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Saibeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"de Franchis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Vecchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2006.10.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jada.2003.08.027"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2990989-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000016911"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177%2F088453360101600606"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1969.tb16024.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2873%2991539-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-199910000-00019"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2898%2900094-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1017%2FS0266462300008710"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01538073"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2898%2900085-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mcg.0000225516.05666.4e"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cgh.2008.12.032"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3748%2Fwjg.14.46"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.dld.2008.05.011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200412000-00008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080%2F003655298750027047"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2003.07632.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3ADDAS.0000004530.11738.a2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS1590-8658%2802%2980087-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200312000-00006"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9270%2800%2902255-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.05690.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/265549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/265549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T19:45:13Z","timestamp":1726170313000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/DIG\/article\/doi\/10.1159\/000265549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,8,1]]},"published-print":{"date-parts":[[2010,8,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000265549","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}