{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:15:43Z","timestamp":1777943743515,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T00:00:00Z","timestamp":1260403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T00:00:00Z","timestamp":1260403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"abstract":"<jats:p>Athymic (nude) mice have played an important role in defining the function of the immune system and its role in infectious diseases. In the majority of these studies, heterozygous +\/nu mice have been used as normal controls for the nu\/nu mice, and it has been assumed that +\/nu mice have essentially normal immune systems. We have compared the response of +\/+, +\/nu and nu\/nu BALB\/c mice following ocular infection with HSV-1 and have found that +\/nu mice develop significantly more severe blepharitis, vascularization of the cornea, stromal keratitis and extraocular disease (herpetiform spread) than +\/+ BALB\/c mice. The extraocular disease was particularly severe in the +\/nu mice, suggesting that factors regulating herpetiform spread of the virus are deficient in these mice. Susceptibility to lethal encephalitis did not differ between +\/+ and +\/nu mice. These results suggest that significant differences exist in the response to ocular HSV infection between +\/+ and +\/nu mice.<\/jats:p>","DOI":"10.1159\/000267189","type":"journal-article","created":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T02:44:11Z","timestamp":1260499451000},"page":"332-337","source":"Crossref","is-referenced-by-count":6,"title":["Susceptibility of +\/+, +\/nu and nu\/nu BALB\/c Mice to Ocular Herpes simplex Virus Infection"],"prefix":"10.1159","volume":"24","author":[{"given":"Curtis R.","family":"Brandt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,10]]},"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000267189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:34:56Z","timestamp":1777707296000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000267189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,10]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1992,6,1]]},"published-print":{"date-parts":[[1992,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000267189","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,10]]}}}