{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:15:49Z","timestamp":1777943749320,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T00:00:00Z","timestamp":1260489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T00:00:00Z","timestamp":1260489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"abstract":"<jats:p>Levels of melatonin in rabbit eye tissues were detected by radioimmunoassay. Solutions of met-enkephalin, leu-enkephalin, \u03b1-endorphin and \u03b2-endorphin were given topically. Met-Enkephalin and \u03b1-endorphin lowered levels of melatonin in the iris, iris root-ciliary body, retina and choroid; leu-enkephalin raised levels in the retina and lowered them in other tissues. \u03b2-Endorphin only lowered levels in the iris root-ciliary body. DAGO (a \u03bc agonist) given i.v. lowered levels of melatonin in the iris, iris root-ciliary body and retina. The \u03b4 and \u03c3 agonists given i.v. only lowered levels in the iris root-ciliary body, and a k agonist given i.v. raised levels in the ciliary body. No opiate binding sites could be detected in the rabbit iris or iris root-ciliay body for any class of receptor. Our data suggest opioids may be useful for treating glaucoma.<\/jats:p>","DOI":"10.1159\/000267340","type":"journal-article","created":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T04:51:26Z","timestamp":1260766286000},"page":"378-385","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Some Opiates and Opioid Peptide Eyedrops on Ocular Melatonin Regulation in Rabbits"],"prefix":"10.1159","volume":"25","author":[{"given":"Brooks H.","family":"Rohde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"El Messiry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George C.Y.","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,11]]},"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000267340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:36:00Z","timestamp":1777707360000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000267340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,11]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1993,6,1]]},"published-print":{"date-parts":[[1993,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000267340","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,11]]}}}