{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:24:34Z","timestamp":1759332274137,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,12,19]],"date-time":"2009-12-19T00:00:00Z","timestamp":1261180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,12,19]],"date-time":"2009-12-19T00:00:00Z","timestamp":1261180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2010]]},"abstract":"In this study, we determined the allele and genotype frequencies of vascular endothelial growth factor (VEGF) <i>G+405C, C\u2013460T<\/i>, <i>C+936T<\/i> and <i>C\u20132578A<\/i> single nucleotide polymorphisms (SNPs) in 32 patients affected by mantle cell lymphoma (MCL) and 58 healthy controls. Real-time PCR combined with melting curve analysis was used for the determination of SNP alleles. A significant difference in the allele frequency of <i>VEGF<\/i><i>C\u2013460T<\/i> and <i>C+936T<\/i> SNPs in MCL and healthy cases was not observed. On the contrary, <i>VEGF G+405C<\/i> and <i>C\u20132578A<\/i> SNP allele distribution was significantly lower in the patient group than among normal controls (p = 0.014, p = 0.001). This observation suggests that further investigation is warranted, both in vitro and in a larger series of patients, to further examine the role of <i>VEGF<\/i> polymorphisms in the pathogenesis of MCL. In addition, the use of quantitative real-time PCR combined with a melting curve analysis method in the detection of the 4 <i>VEGF<\/i> SNPs may have the potential to replace older and more time-consuming PCR-RFLP methods and bears further investigation.<\/jats:p>","DOI":"10.1159\/000267826","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T08:00:14Z","timestamp":1261468814000},"page":"91-95","source":"Crossref","is-referenced-by-count":13,"title":["Vascular Endothelial Growth Factor Polymorphisms in Mantle Cell Lymphoma"],"prefix":"10.1159","volume":"123","author":[{"given":"S.","family":"Galimberti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A.","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ciancia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Buda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Orciuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Melosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lambelet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ronca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.01.1825"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.08.133"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm0603-669"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1530%2Frep.0.1210181"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0198-8859%2899%2900132-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000054076"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fcyto.2000.0692"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpheart.01033.2005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F1042819031000123519"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2002.03253.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cca.2007.12.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lungcan.2009.02.020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fmc.20572"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2006.12.021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.oraloncology.2004.12.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2217%2Fpgs.09.54"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fadpa.2003.50000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1006%2Fcyto.2000.0692"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000054076"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190902856808"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/267826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/267826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:35:10Z","timestamp":1745440510000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000267826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,19]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000267826","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2009,12,19]]}}}