{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:46:12Z","timestamp":1775076372843,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Insulinoma is a rare and potentially curable disease. It is often misdiagnosed as neurological or psychiatric disorder. This study was performed to characterize the neuropsychiatric symptoms (PNS) of the patients with insulinoma from a regional clinical center. &lt;i&gt;Methods:&lt;\/i&gt; All medical records of the patients with histopathologically identified insulinoma were reviewed during the period from 1998 to 2008. A case-control analysis was performed to compare the demographic data, details of clinical presentation, biochemical findings, tumor localization, and intraoperative findings between the patients with and without a prior misdiagnosis. &lt;i&gt;Results:&lt;\/i&gt; Among 42 patients with insulinoma, 25 patients with PNS were initially misdiagnosed as having a neurological or psychiatric disease, while 17 patients with no PNS were correctly diagnosed. Most (64%) of PNS cases were not diagnosed correctly until 12 months after the first consultation. In patients with PNS that remained undiagnosed for at least 5 years, the most frequent symptoms were confusion, convulsion, and visual disturbances. Twelve cases of PNS were initially misdiagnosed as epilepsy and 3 of them showed epileptiform discharges on electroencephalography. &lt;i&gt;Conclusions:&lt;\/i&gt; Episodic hypoglycemia induced by insulinoma can greatly mimic neurological and psychiatric presentation. A thorough history taking and inpatient assessment are necessary in evaluating recurrent neurological and psychiatric symptoms.<\/jats:p>","DOI":"10.1159\/000268166","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T08:12:31Z","timestamp":1261555951000},"page":"48-51","source":"Crossref","is-referenced-by-count":26,"title":["Neuropsychiatric Profiles of Patients with Insulinomas"],"prefix":"10.1159","volume":"63","author":[{"given":"Yao","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1528-1167.2005.00253.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.029249"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1631%2Fjzus.B0720011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1052-3057%2897%2980220-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1385%2FENDO%3A19%3A2%3A127"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpendmet1046"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2899%2900021-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199309163291203"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpendo.00539.2003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00431-006-0365-z"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.1981.tb10820.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nbd.2007.03.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fpgmj.60.707.577"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410240602"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/268166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/268166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:38:18Z","timestamp":1745440698000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000268166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,23]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000268166","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,23]]}}}