{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:24:39Z","timestamp":1777890279274,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"abstract":"<jats:p>Fragestellung: Welche neueren histologischen Prognosefaktoren sind f\u00fcr das Vulvakarzinom von Bedeutung? Methoden: 147 prim\u00e4re Plattenepithelkarzinomen wurden hinsichtlich rezidivfreiem- und Gesamt\u00fcberleben untersucht (mittl. Beobachtungszeit 59,6 Mon.). Ergebnisse: Signifikante Bedeutung f\u00fcr die Prognose besa\u00dfen das FIGO-Stadium, ein neu-etabliertes Gradingverfahren, die p53- und Vimentin-Expression sowie die H\u00e4ufigkeit von T-Lymphozyten im Tumorstroma. Klinisch mit ung\u00fcnstiger Prognose verbunden waren weiter eine hohe Wachstumsfraktion (MIB-1), ein hohes proliferierendes Zellkompartiment (S + G2 + M) sowie Cytokeratin-8-Expression. Schlu\u00dffolgerungen: Beim Vulvakarzinom erm\u00f6glichen die genannten Untersuchungen einen entscheidenden Beitrag zur Prognoseeinsch\u00e4tzung und sollten die Entscheidung f\u00fcr ein eingeschr\u00e4nktradikales Therapieverfahren beeinflussen.<\/jats:p>","DOI":"10.1159\/000272556","type":"journal-article","created":{"date-parts":[[2009,12,24]],"date-time":"2009-12-24T03:16:40Z","timestamp":1261624600000},"page":"11-14","source":"Crossref","is-referenced-by-count":1,"title":["Neuere Prognosefaktoren des Vulvakarzinoms: Histologische, Immunhistochemische und durchflu\u00dfzytometrische Untersuchungen"],"prefix":"10.1159","author":[{"given":"W.","family":"Weikel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Moll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brumm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.G.","family":"Knapstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,23]]},"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000272556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:33:58Z","timestamp":1777613638000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000272556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000272556","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"value":"1018-8843","type":"print"},{"value":"1423-0011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,23]]}}}