{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:24:32Z","timestamp":1777890272701,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"abstract":"<jats:p>Fragestellung: Eine serologische Untersuchung f\u00fcr genitale HPV Infektion w\u00fcrde zus\u00e4tzlich zu den HPV-DNA-Untersuchungsmethoden wichtige Informationen liefern, da sie auch zur\u00fcckliegende Infektionen erfassen w\u00fcrde, eine signifikante immunologische Antwort auf die Virusinfektion anzeigen und in alien klinischen Labors durchgef\u00fchrt werden k\u00f6nnte. Methoden: Serumproben dreier gyn\u00e4kologischer Patientengruppen wurden in einem direkten ELISA auf spezifische IgG-Antik\u00f6rper gegen bakulovirusexprimierte HPV-6- und BPV-1-L1-VLPs un-tersucht. Ergebnisse: Positive IgG-Reaktionen gegen HPV-6-L1-VLPs zeigten 6% von 72 Kontrollpatientinnen, 43% von 73 Kondylompatientinnen, 27% von 62 CIN-Patientinnen. Die individuellen IgG-ELISA-Werte der Kondylom- und CIN-Patientinnen f\u00fcr HPV-6-L1-VLPs zeigten keine Korrelation zu den Ergebnissen mit BPV-1-L1-VLPs. Schlu\u03b2folgerungen: Die Ergebnisse zeigen, da\u03b2 HPV-6-L1-VLPs ein wirksames Antigen f\u00fcr serologische Untersuchungen darstellen und speziesspezifische Antik\u00f6rper erkannt werden k\u00f6nnen, womit sich wichtige Perspektiven f\u00fcr die Diagnostik, Epidemiologie, Einblicke in den nat\u00fcrlichen Krankheitsverlauf, die Prognose der Infektion und f\u00fcr die \u00dcberpr\u00fcfung einer Impfung ergeben.<\/jats:p>","DOI":"10.1159\/000272559","type":"journal-article","created":{"date-parts":[[2009,12,24]],"date-time":"2009-12-24T03:16:40Z","timestamp":1261624600000},"page":"25-31","source":"Crossref","is-referenced-by-count":1,"title":["Spezifische serologische Untersuchungen mit einem neuartigen authentischen HPV-Antigen (Virus-like Particles) auf HPV-6 Antik\u00f6rper bei gyn\u00e4kologischen Patientenkollektiven"],"prefix":"10.1159","author":[{"given":"K.","family":"Heim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.D.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"H\u00f6pfl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wartusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zeimet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Larcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ruth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bergant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pirschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Dierich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.W.","family":"Kreider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Dapunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,12,23]]},"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000272559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:33:59Z","timestamp":1777613639000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000272559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000272559","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"value":"1018-8843","type":"print"},{"value":"1423-0011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,23]]}}}