{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:41:33Z","timestamp":1745469693692,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; Programmed death-1 (PD-1) is physiologically expressed by germinal center (GC)-associated helper T cells. It has been proposed that an increase in PD-1+ cells outside GC could indicate pattern I angioimmunoblastic T-cell lymphoma (AITL). &lt;i&gt;Methods:&lt;\/i&gt; We studied the distribution of PD-1+ cells in reactive lymphadenopathies (LA), including HIV-associated and dermatopathic LA (n = 5, each), Castleman (n = 3), Kikuchi (n = 2) and Rosai-Dorfman diseases (n = 1), sarcoidoses (n = 7) and follicular hyperplasias (n = 8). &lt;i&gt;Results:&lt;\/i&gt; The highest concentrations of PD-1+ cells in GC were found in Castleman and Rosai-Dorfman diseases (mean 57 and 50% of total cells, respectively), and the lowest in HIV-associated LA (mean 6%). The highest proportions in paracortices were found in Castleman disease, and in HIV-associated and dermatopathic LA (mean 7, 3 and 2%, respectively). PD-1+ cells predominated in the pale zones of GC in follicular hyperplasia. In HIV-associated LA, PD-1+ cells showed marked marginalization in the GC. No paracortical PD-1+ cells were found in sarcoidoses and Rosai-Dorfman disease. &lt;i&gt;Conclusions:&lt;\/i&gt; The varying distribution of PD-1+ cells in defined LA might indicate a functional relevance of these cells in the respective entities. Since increased numbers of PD-1+ cells outside GC are observed in various LA, this finding might not be entirely specific for pattern I AITL.<\/jats:p>","DOI":"10.1159\/000272951","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T09:20:08Z","timestamp":1267435208000},"page":"24-27","source":"Crossref","is-referenced-by-count":11,"title":["Distribution of PD-1+ Lymphocytes in Reactive Lymphadenopathies"],"prefix":"10.1159","volume":"77","author":[{"given":"Simone","family":"Muenst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Dirnhofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.pas.0000209855.28282.ce"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fni1165"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F85330"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature04444"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3324%2Fhaematol.10864"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4065%2F70.10.969"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2004.05311.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2F443282a"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2174%2F1570162043485068"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1513%2Fpats.200606-130MS"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/272951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/272951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:48:57Z","timestamp":1745441337000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000272951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000272951","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2010]]}}}