{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:26:39Z","timestamp":1781677599612,"version":"3.54.5"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the safety, tolerability and efficacy of adjuvant intravesical gemcitabine versus bacillus Calmette-Gu\u00e9rin (BCG) in the treatment of high-risk superficial bladder cancer. &lt;i&gt;Method:&lt;\/i&gt; 64 patients with high-risk superficial bladder cancer (pT1 and\/or G3 and\/or CIS) were assigned to interventions (gemcitabine or BCG) in a randomised controlled trial. All the patients were evaluated for recurrence and progression rates (primary endpoint) and safety and tolerability (secondary endpoint). &lt;i&gt;Results:&lt;\/i&gt; The two groups were comparable in terms of baseline characteristics. Tolerability was better for gemcitabine, whereas the BCG group experienced the need for delayed treatment or withdrawal in 12.5% of cases. At a mean follow-up of 44 months, the recurrence rate in patients treated with BCG was 28.1%; the recurrence rate in patients who received gemcitabine was 53.1% (p = 0.037). Time to recurrence was shorter in patients treated with BCG (25.6 vs. 39.4 months, p = 0.042). No patients developed disease progression. &lt;i&gt;Conclusions:&lt;\/i&gt; Gemcitabine is significantly inferior to BCG, but given its favourable toxicity profile, it may be useful for patients intolerant to or otherwise unable to receive BCG.<\/jats:p>","DOI":"10.1159\/000273461","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T11:28:13Z","timestamp":1266492493000},"page":"23-27","source":"Crossref","is-referenced-by-count":59,"title":["Bacillus Calmette-Gu\u00e9rin versus Gemcitabine for Intravesical Therapy in High-Risk Superficial Bladder Cancer: A Randomised Prospective Study"],"prefix":"10.1159","volume":"84","author":[{"given":"Massimo","family":"Porena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Del Zingaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Lazzeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Mearini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Giannantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Bini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Costantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000112600"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2005.12.031"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000111734"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2007.08.015"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1517%2F14656566.8.18.3265"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2FCAD.0b013e328010ef47"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdj966"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000090870"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2004.05.035"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.09.028"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000066121"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000087162"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199512000-00025"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0302-2838%2801%2900026-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000089164"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2003.04656.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2006.08.038"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2002.02.066"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2003.09.014"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000111737"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2007.08.015"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2965396-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS1569-9056%2807%2960148-1"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/273461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/273461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:49:02Z","timestamp":1745441342000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000273461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000273461","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}