{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:57:53Z","timestamp":1787320673564,"version":"build-2736575974"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background and Objective:&lt;\/i&gt; We assessed the antioxidant activity of dexmedetomidine (DEX) during an ischemic period in a rat model of testicular torsion\/detorsion (T\/DT) by using biochemical and histopathological methods. &lt;i&gt;Methods:&lt;\/i&gt; Wistar Albino male rats weighing 250\u2013300 g were divided into three groups: sham (group S, n = 7); torsion\/detorsion (group T\/DT, n = 7), and DEX treatment (group DEX, n = 7). In the T\/DT group, right testes were rotated 720\u00b0 for 1 h. Group S served for normal basal values. Rats in group T\/DT were operated to make T\/DT, this group served as a control group. Group DEX received intraperitoneal DEX 10 \u00b5g \u00b7 kg&lt;sup&gt;\u20131&lt;\/sup&gt; after the 30-min torsion period. For measurement of total antioxidant enzyme activities and malondialdehyde (MDA) levels, testes of 7 animals in each group were excised after 4 h of reperfusion. Germ cell apoptosis was evaluated using the apoptosis protease-activating factor 1 (APAF-1) antibody in all groups and also on the expressions of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) were assessed within the bilateral testes. &lt;i&gt;Results:&lt;\/i&gt; Mean MDA levels in group T\/DT were significantly higher than in groups S and DEX (p &lt; 0.05). There were also significant decreases in mean total antioxidant activities in group T\/DT when compared to groups S and DEX (p &lt; 0.05). These values were significantly higher in group DEX than group T\/DT. Germ cell apoptosis, eNOS and iNOS levels were significantly higher in group T\/DT when compared to groups S and DEX (p &lt; 0.05). &lt;i&gt;Conclusions:&lt;\/i&gt; DEX treatment has potential biochemical and histopathological benefits by preventing ischemia\/reperfusion-related cellular damage in an experimental testicular torsion model. Preference of DEX for anesthesia during the detorsion procedure may attenuate ischemia-reperfusion injury.<\/jats:p>","DOI":"10.1159\/000273476","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T06:28:13Z","timestamp":1266474493000},"page":"105-111","source":"Crossref","is-referenced-by-count":48,"title":["Effect of Dexmedetomidine on Testicular Torsion\/Detorsion Damage in Rats"],"prefix":"10.1159","volume":"84","author":[{"given":"Volkan","family":"Hanc\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Bekta\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6rkem","family":"Mungan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhan","family":"Yurtlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcsn\u00fc","family":"Tokg\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u015f\u0131l","family":"\u00d6zko\u00e7ak Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00345-008-0243-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-007-2058-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00345-004-0451-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpedsurg.2008.01.065"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F01.aco.0000174958.05383.d5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhsa.2008.01.014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.resuscitation.2007.01.032"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00000539-200302000-00041"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-199708000-00025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00300075"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2894%2980105-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109%2F01485019808988547"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2963295-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000030382"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-6576.2006.01145.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-6576.2007.01545.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2899%2900186-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020170071"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-199308000-00016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-199108000-00022"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2897%2900585-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-005-1580-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainres.2008.04.045"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod65.2.514"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2002-0142"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0024-3205%2803%2900593-9"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3468%2803%2900573-6"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/273476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/273476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:49:07Z","timestamp":1745426947000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000273476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000273476","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}