{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:48:46Z","timestamp":1791132526414,"version":"4.1.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Epidemiological and microbiologic studies suggest that enteropathogenic microorganisms play a substantial role in the clinical initiation and relapses of inflammatory bowel disease. <i>Aim:<\/i> To explore the prevalence of intestinal protozoa in patients with ulcerative colitis (UC) and its impact on clinical disease course. <i>Methods:<\/i> A total of 215 patients with definitive diagnosis of UC were studied. Fresh feces samples taken from all UC patients were examined immediately using trichrome-staining methods. <i>Results:<\/i> A total of 103 female and 112 male UC patients were analyzed. The mean age at diagnosis was 30.5 \u00b1 10.8 years. The prevalence of overall parasitic infections was 24% and distributed as follows: <i>Blastocystis hominis <\/i>in 22 patients (10%), <i>Endolimax nana <\/i>in 19 cases (9%), and <i>Entamoeba<\/i><i>histolytica <\/i>in 11 cases (5%). A significantly increased frequency of protozoa infection was found in those patients with persistent activity and intermittent activity as compared to active than inactive group (p = 1 \u00d7 10<sup>\u20137<\/sup>, OR 13.05, 95% CI 4.28\u201342.56, and p = 0.003, OR 1.42\u201314.47, respectively). Interestingly, this association remained significant when we compared the persistent activity group versus intermittent activity group (p = 0.003, OR 2.97, 95% CI 1.35\u20136.59). Subgroup analysis showed no association between protozoa infection (<i>E. histolytica, B. hominis, and E. nana)<\/i> and other clinical variables such as gender, extent of disease, extraintestinal complications, medical treatment and grade of disease activity. <i>Conclusion:<\/i> The prevalence of intestinal protozoa infections in Mexican UC patients was 24% and these microorganisms could be a contributing cause of persistent activity despite medical treatment in our population.<\/jats:p>","DOI":"10.1159\/000273871","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T08:37:49Z","timestamp":1265704669000},"page":"18-23","source":"Crossref","is-referenced-by-count":41,"title":["Intestinal Protozoa Infections among Patients with Ulcerative Colitis: Prevalence and Impact on Clinical Disease Course"],"prefix":"10.1159","volume":"82","author":[{"given":"Jes\u00fas K.","family":"Yamamoto-Furusho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Torijano-Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FMCG.0b013e31817a76b4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.MIB.0000225339.91484.fc"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748%2Fwjg.14.5125"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.150.7.1514"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2008.05.081"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fibd.20539"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2009.04062.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2004.04.061"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/273871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/273871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:53:25Z","timestamp":1745441605000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000273871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,4,1]]},"published-print":{"date-parts":[[2010,4,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000273871","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}