{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:24:46Z","timestamp":1760189086836,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Fibroblast growth factor 23 (FGF23) has been shown to suppress parathyroid hormone (PTH) secretion. \u03b1-Klotho has been demonstrated to function as a fibroblast growth factor receptor (FGFR) cofactor for FGF23. Thus, both \u03b1-Klotho and FGFR may play roles in PTH synthesis and\/or secretion. Functions of \u03b1-Klotho and FGFR in secondary hyperparathyroidism (SHPT) remain to be studied. The present studies explore the role of \u03b1-Klotho and FGFR in SHPT. &lt;i&gt;Methods:&lt;\/i&gt; Hyperplastic parathyroid glands (n = 44) were obtained from patients with SHPT. &lt;i&gt;Results:&lt;\/i&gt; Immunohistochemical study showed that both \u03b1-Klotho and FGFR1c expression in hyperplastic glands was significantly decreased compared with that in normal glands (Klotho p &lt; 0.01, and FGFR1c p &lt; 0.05). A significant positive correlation was observed between \u03b1-Klotho and FGFR1c (r&lt;sup&gt;2&lt;\/sup&gt; = 0.375, p &lt; 0.01) indicating a cooperative system. Both \u03b1-Klotho (r&lt;sup&gt;2&lt;\/sup&gt; = 0.235, p &lt; 0.05) and FGFR1c (r&lt;sup&gt;2&lt;\/sup&gt; = 0.181, p &lt; 0.05) correlated positively with the calcium-sensing receptor (CaR), which plays an important role in the development of SHPT. In addition, expression of \u03b1-Klotho correlated negatively with parathyroid cell proliferation, as confirmed by Ki67 staining (r&lt;sup&gt;2&lt;\/sup&gt; = 0.148, p &lt; 0.05). &lt;i&gt;Conclusion:&lt;\/i&gt; Decreased expression of \u03b1-Klotho and FGFR1c in parallel with CaR expression and parathyroid cell growth may be involved in the pathogenesis of SHPT.<\/jats:p>","DOI":"10.1159\/000274483","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T11:45:38Z","timestamp":1262864738000},"page":"230-238","source":"Crossref","is-referenced-by-count":39,"title":["Involvement of Alpha-Klotho and Fibroblast Growth Factor Receptor in the Development of Secondary Hyperparathyroidism"],"prefix":"10.1159","volume":"31","author":[{"given":"Chiaki","family":"Kumata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Mizobuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Koiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kadokura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Kinugasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Akizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00000441-199906000-00004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.5.2000"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI116720"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1997.41"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.4.1598"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198706183162504"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2002.kid585.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2000.00370.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00041552-199607000-00008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.2005.00302.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00302.2004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004080657"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00386.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.00027.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2002.17.12.2206"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2FMNH.0b013e328303e172"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.642"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI36479"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00018-008-8177-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2008-0564"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M201804200"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.0080904"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00396.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11255-008-9466-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00328.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.2005.00291.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00184.x"}],"container-title":["American 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