{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:13:36Z","timestamp":1757452416838,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objective:<\/i> To investigate first-trimester ADAM-12 levels in pregnancies which later develop hypertensive and growth complications. <i>Methods:<\/i> First-trimester serum samples (11<sup>+0<\/sup> to 13<sup>+6<\/sup> weeks) were retrieved from frozen storage. 47 samples with at least one of the following adverse outcomes: pre-eclampsia (PE), small for gestational age, HELLP syndrome and gestational hypertension were analysed and 452 controls matched to the cases by gestational age and length of storage were analysed. ADAM-12 levels were measured by the automated AutoDELFIA immunoassay platform. <i>Results: <\/i>ADAM-12 was found to increase with gestational age (11<sup>+0<\/sup> to 13<sup>+6<\/sup> weeks) and decrease with increasing maternal weight and in women who smoked. After correction, ADAM-12 median multiples of the median were increased in cases with <i>HELLP<\/i> syndrome, <i>all PE<\/i> and <i>PE only<\/i>. <i>Conclusion:<\/i> The increased first-trimester levels of ADAM-12 in <i>PE<\/i> and <i>HELLP<\/i> are in contrast with previous findings. The usefulness of ADAM-12 as a marker for adverse outcomes is still unclear.<\/jats:p>","DOI":"10.1159\/000275669","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T07:54:26Z","timestamp":1264406066000},"page":"32-39","source":"Crossref","is-referenced-by-count":12,"title":["Maternal Serum ADAM-12 as a Potential Marker for Different Adverse Pregnancy Outcomes"],"prefix":"10.1159","volume":"27","author":[{"given":"E.","family":"Matwejew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.J.","family":"Cowans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stamatopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.S.","family":"von Kaisenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2991224-A"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7200165"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903599-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903577-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.curobgyn.2003.10.009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902800-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bpobgyn.2004.02.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1251"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1664"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fuog.6212"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.27.16993"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.2000.3835"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M002172200"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.762"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1480"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1540"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1885"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1978"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1939"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1750"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.2043"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1957"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1665"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.2141"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1996.tb14164.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.708"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1581"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00109-005-0714-9"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1080%2F14767050701483389"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/275669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/275669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:13:25Z","timestamp":1745442805000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000275669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000275669","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2010]]}}}