{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:36:52Z","timestamp":1789756612043,"version":"4.0.1"},"reference-count":37,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Protocol biopsies offer new possibilities to predict kidney allograft outcome. The aim of this study was to find clinical, laboratory, morphological and molecular predictors of short-term renal graft survival. &lt;i&gt;Methods:&lt;\/i&gt; Three-month protocol kidney graft biopsy was carried out on 257 patients. The real-time RT-PCR was used to identify intragraft mRNA expression of several cytokines and chemokines and predictive statistics was performed to find markers connected with the risk of premature graft failure. &lt;i&gt;Results:&lt;\/i&gt; Compared to patients with normal morphology at 3 months, patients with subclinical rejection including borderline changes had experienced more frequent (p &lt; 0.001) acute rejections before 3-month biopsy, serum creatinine \u2267170 \u00b5mol\/l (p &lt; 0.01), and higher intrarenal expression of RANTES, IP-10 (p &lt; 0.001), C3, CD3, IgJ (p &lt; 0.01) and CD20 (p &lt; 0.05). There was a significant correlation between subclinical rejection and the occurrence of late acute rejection and graft failure at the first year after transplantation. Moreover, higher RANTES and IP-10 expressions in subclinical rejection predicted graft loss at one year after transplantation in the univariate analysis. &lt;i&gt;Conclusions:&lt;\/i&gt; Patients with subclinical rejection including borderline changes in 3-month biopsy and particularly those with higher intrarenal expression of RANTES and IP-10 mRNA were found to be at risk for premature kidney graft loss.<\/jats:p>","DOI":"10.1159\/000275705","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T08:25:59Z","timestamp":1263543959000},"page":"7-14","source":"Crossref","is-referenced-by-count":13,"title":["Potential Predictive Markers in Protocol Biopsies for Premature Renal Graft Loss"],"prefix":"10.1159","volume":"33","author":[{"given":"Ivo","family":"Matl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hribova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Honsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Brabcova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Viklicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-200102270-00006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006030227"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-6143.2002.20301.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005050463"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199502150-00001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001470050124"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2004.12.177"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00050.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000328"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-6143.2003.00072.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2006.01688.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000126928.15055.DC"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2006.01436.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-2277.2007.00535.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F01.tp.0000225783.86950.c2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-200005150-00019"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.00390705"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000128328.68106.54"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000062835.30165.2C"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2005.00830.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-0012.17.s10.6.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2006.01635.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2907875-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199704150-00013"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-200206270-00023"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0041-1345%2803%2900616-X"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-2277.2004.00020.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000082542.99416.11"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2004.00526.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.2.695"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199911270-00024"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199812270-00018"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0012.2004.00170.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa035588"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1097%2F01.tp.0000250572.46679.45"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.2174%2F138920208785133235"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mnh.0000214770.11609.fb"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/275705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/275705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:14:09Z","timestamp":1745442849000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000275705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000275705","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}