{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:33:37Z","timestamp":1777944817067,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"abstract":"<jats:p>Substance P- and neuropeptide Y-like immunoreactivity was demonstrated by immunohistochemical methods in mucosal specimens from the middle ear cleft of the guinea pig and rat. Substance P-like immunoreactivity was seen in corresponding specimens of the rabbit. Substance P-like immunoreactivity was also demonstrated in the tympanic nerve of various animal species and man. These specimens also showed weak immunoreactivity for bombesin. The findings suggest the presence of substance P in the tympanic nerve. Theoretically substance P may act in the middle ear cleft mucosa in several ways. One possibility is its putative role in the neurochemical control of the middle ear aeration. Another hypothetical possibility is a role in the neurogenic inflammation after noxious stimulation of the middle ear mucosa.<\/jats:p>","DOI":"10.1159\/000275987","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T03:13:29Z","timestamp":1263179609000},"page":"176-182","source":"Crossref","is-referenced-by-count":9,"title":["Neuropeptides in the Middle Ear Mucosa"],"prefix":"10.1159","author":[{"given":"J.","family":"Ylikoski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Panula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,8]]},"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000275987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:20:57Z","timestamp":1777710057000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000275987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000275987","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,8]]}}}