{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:30:24Z","timestamp":1790163024045,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Excessive daytime sleepiness (EDS) is frequent in patients with Parkinson\u2019s disease (PD). Occasionally, EDS in PD exhibits narcolepsy-like features. We aimed to assess characteristics and determinants of EDS in consecutive patients with PD. &lt;i&gt;Methods:&lt;\/i&gt; Thirty consecutive patients with PD underwent a detailed clinical examination. EDS was assessed using the Epworth Sleepiness Scale (ESS) and Multiple Sleep Latency Test (MSLT). Sleep was assessed using video-polysomnography. Cerebrospinal fluid (CSF) hypocretin-1 levels were obtained in 3 patients. &lt;i&gt;Results:&lt;\/i&gt; ESS was &gt;10 in 17 patients (57%). Mean sleep latency (MSL) on MSLT was &lt;5 min in 11 patients (37%). There was a significant negative correlation between ESS and MSL. None of the 11 patients with MSL &lt;5 min showed a sleep onset REM (SOREM) episode. Patients with EDS had higher dopamine agonists\/levodopa equivalent doses, higher apnea\/hypopnea index and exhibited wearing-off symptoms more often. Hypocretin-1 was normal in 3 patients tested. &lt;i&gt;Conclusion:&lt;\/i&gt; EDS, which can sometimes be severe, is common in PD patients even in the absence of SOREM and detectable CSF-hypocretin deficiency. In PD, EDS is a multifaceted phenomenon, the determinants of which include severity of PD, wearing-off symptoms, dosage of antiparkinsonian drugs and sleep-disordered breathing.<\/jats:p>","DOI":"10.1159\/000276402","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T13:14:48Z","timestamp":1263820488000},"page":"129-135","source":"Crossref","is-referenced-by-count":89,"title":["Excessive Daytime Sleepiness in Parkinson\u2019s Disease: Characteristics and Determinants"],"prefix":"10.1159","volume":"63","author":[{"given":"R.","family":"Poryazova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Benninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Waldvogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Bassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.61.1.97"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2869.2000.00201.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1389-9457%2803%2900058-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2004.00971.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2005.12.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-005-0614-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.21002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020170098"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000233980.25978.9d"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10417"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10193"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.6.986"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2005.03.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm097"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm090"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2006.08.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.51.6.745"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2869.2004.00422.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.10.1553"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.smrv.2005.01.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.287.4.455"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawl079"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS1389-9457%2803%2900105-9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00441-004-0956-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature04284"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature04767"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10365"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10429"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:21:40Z","timestamp":1745443300000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000276402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000276402","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}