{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:08:45Z","timestamp":1761718125775,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"7-8","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>A population-based cystic fibrosis (CF) carrier screening program was introduced in Victoria, Australia in 2006, and was offered to couples planning a pregnancy or in early pregnancy for a fee. Individuals received pre-test advice from their doctor and through a brochure. Carriers identified received genetic counseling. The aim of this study was to assess the attitudes of people undertaking screening. Between January 2006 and June 2008 all carriers (n = 79) and a randomly selected cohort of non-carriers (n = 162) were invited to participate. A purpose-designed questionnaire explored the following domains: knowledge, recollection and meaning of carrier status, reasons for having screening, anxiety and communication of results to family members. Forty-seven carriers (62%) and 65 non-carriers (41%) returned the questionnaire. Most participants were female (97%) aged 35\u201339 (46%). The main reasons for choosing screening were the perception of CF as a severe condition and a doctor\u2019s recommendation. All carriers correctly recalled their carrier status and the risk of having a child with CF, while 3 non-carriers (4.7%) were unsure of their carrier status and 12 (22%) incorrectly recalled their residual risk. Carriers answered the knowledge questions correctly more often than non-carriers. There was no difference in anxiety between carriers and non-carriers. The majority of carriers informed relatives of their increased risk of being a carrier. We conclude that participants\u2019 attitude towards carrier screening for CF was generally very positive. Our model of screening could be applied on a larger scale.<\/jats:p>","DOI":"10.1159\/000276544","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T08:26:10Z","timestamp":1263543970000},"page":"449-456","source":"Crossref","is-referenced-by-count":27,"title":["Population-Based Genetic Screening for Cystic Fibrosis: Attitudes and Outcomes"],"prefix":"10.1159","volume":"13","author":[{"given":"L.","family":"Ioannou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Massie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"McClaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.B.","family":"Delatycki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.5.1177"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra043184"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.46.12.881"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00125817-200103000-00010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1096-8628%2820000731%2993%3A3%3C198%3A%3AAID-AJMG7%3E3.0.CO%3B2-Q"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F01.gim.0000187162.28070.a7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejhg.5201965"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970150615"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.38.10.695"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1569-1993%2808%2960044-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819971231%2973%3A4%3C378%3A%3AAID-AJMG2%3E3.0.CO%3B2-K"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2105%2FAJPH.82.5.723"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1089%2F109065702761403351"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.c.10008"}],"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:23:18Z","timestamp":1745443398000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000276544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":14,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000276544","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"type":"print","value":"1662-4246"},{"type":"electronic","value":"1662-8063"}],"subject":[],"published":{"date-parts":[[2010]]}}}