{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:55:16Z","timestamp":1773147316574,"version":"3.50.1"},"reference-count":8,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; BRCA mutation carriers have a high lifetime risk of developing breast and ovarian malignancies. As genetic testing becomes widely available, preventative measures are a choice. We evaluated the characteristics of BRCA mutation carriers who chose prophylactic surgery (PS) compared to those who opted for surveillance. &lt;i&gt;Methods:&lt;\/i&gt; A retrospective chart review of patients with a mutation in the BRCA1 or BRCA2 genes was performed. &lt;i&gt;Results:&lt;\/i&gt; Ninety women were included, of whom 46 (51%) underwent PS. They were more likely to be a BRCA2 mutation carrier, parous, married, employed, and had a prior history of breast cancer. PS included 39 bilateral salpingo-oophorectomies and 13 mastectomies. Pathology was typically benign; however, 15% showed ductal carcinoma in situ of the breast, 8% reported infiltrating ductal carcinoma of the breast, 3% was adenocarcinoma of the fallopian tube, and 3% was adenocarcinoma of the ovary. &lt;i&gt;Conclusion:&lt;\/i&gt; It is notable that BRCA1 mutation carriers were less inclined to elect for PS. Evaluating the reasons for pursuing PS among women with a BRCA mutation is necessary and will require a larger data set. Long-term follow-up is required to describe the potential side effects of PS on quality of life.<\/jats:p>","DOI":"10.1159\/000276573","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T07:54:26Z","timestamp":1264406066000},"page":"270-273","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Characteristics and Choices Regarding Risk-Reducing Surgery in BRCA Mutation Carriers"],"prefix":"10.1159","volume":"69","author":[{"given":"Ashley","family":"Stuckey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Dizon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Scalia Wilbur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Kent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Tejada-Berges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Gass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Legare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1086%2F301749"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199705153362001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2991578-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.04.086"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchsurg.138.12.1323"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.09.052"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.02.626"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22352"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:23:48Z","timestamp":1745443428000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000276573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000276573","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}