{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:43:19Z","timestamp":1745469799483,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Lipoprotein glomerulopathy (LPG) is a unique disease characterized by thrombus-like lipoprotein deposition in glomeruli and an increased serum apolipoprotein E level (ApoE protein or APOE gene). Several APOE mutations contribute to the occurring of LPG. &lt;i&gt;Methods:&lt;\/i&gt; We confirmed LPG in 7 individuals by renal biopsy, and investigated families of 2 patients with urinalysis, serum creatinine and serum lipid examination. Exons of APOE of all individuals as well as their relatives were amplified and sequenced directly. &lt;i&gt;Results:&lt;\/i&gt; Two types of APOE mutations were identified in the 7 patients and their relatives. APOE Maebashi (Arg142-Leu144\u21920) heterozygotes were found in 5 individuals who were from 4 different families. APOE Kyoto (Arg25-Cys) was confirmed heterogeneous in another 2 individuals. Both mutations present incomplete penetrance. &lt;i&gt;Conclusion:&lt;\/i&gt; Our research indicates that APOE Maebashi (Arg142-Leu144\u21920) is a common mutation in Chinese LPG. However, not all carriers of the 2 mutations have LPG, although hyperlipidemia and high serum ApoE level are tested. There are likely other reasons, such as a local mechanism in the glomeruli, which participated in the renal injury.<\/jats:p>","DOI":"10.1159\/000276578","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T10:00:38Z","timestamp":1263981638000},"page":"c260-c267","source":"Crossref","is-referenced-by-count":13,"title":["Common Apolipoprotein E Gene Mutations Contribute to Lipoprotein Glomerulopathy in China"],"prefix":"10.1159","volume":"114","author":[{"given":"Jia","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongli","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMc072088"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2005.10.017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fhumu.1380040303"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00677.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000045513"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00572.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004670050032"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M005906200"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fmeta.2002.29990"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000111828"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M710457200"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2003.50016"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004670050264"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1163%2Fej.9789004175679.i-303.18"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm675"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm735"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/276578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:23:52Z","timestamp":1745443432000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000276578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,20]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000276578","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2010,1,20]]}}}