{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:35:17Z","timestamp":1791999317900,"version":"4.4.0"},"reference-count":177,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Syndromol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Noonan syndrome (NS) is a relatively common, clinically variable and genetically heterogeneous developmental disorder characterized by postnatally reduced growth, distinctive facial dysmorphism, cardiac defects and variable cognitive deficits. Other associated features include ectodermal and skeletal defects, cryptorchidism, lymphatic dysplasias, bleeding tendency, and, rarely, predisposition to hematologic malignancies during childhood. NS is caused by mutations in the &lt;i&gt;PTPN11&lt;\/i&gt;, &lt;i&gt;SOS1&lt;\/i&gt;, &lt;i&gt;KRAS&lt;\/i&gt;, &lt;i&gt;RAF1&lt;\/i&gt;, &lt;i&gt;BRAF&lt;\/i&gt; and &lt;i&gt;MEK1 (MAP2K1)&lt;\/i&gt; genes, accounting for approximately 70% of affected individuals. SHP2 (encoded by &lt;i&gt;PTPN11&lt;\/i&gt;), SOS1, BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations. Similarly, reduced GTPase activity or increased guanine nucleotide release underlie the aberrant signal flow through the MAPK cascade promoted by most &lt;i&gt;KRAS&lt;\/i&gt; mutations. More recently, a single missense mutation in &lt;i&gt;SHOC2&lt;\/i&gt;, which encodes a cytoplasmic scaffold positively controlling RAF1 activation, has been discovered to cause a closely related phenotype previously termed Noonan-like syndrome with loose anagen hair. This mutation promotes aberrantly acquired N-myristoylation of the protein, resulting in its constitutive targeting to the plasma membrane and dysregulated function. &lt;i&gt;PTPN11&lt;\/i&gt;, &lt;i&gt;BRAF&lt;\/i&gt; and &lt;i&gt;RAF1&lt;\/i&gt; mutations also account for approximately 95% of LEOPARD syndrome, a condition which resembles NS phenotypically but is characterized by multiple lentigines dispersed throughout the body, caf\u00e9-au-lait spots, and a higher prevalence of electrocardiographic conduction abnormalities, obstructive cardiomyopathy and sensorineural hearing deficits. These recent discoveries demonstrate that the substantial phenotypic variation characterizing NS and related conditions can be ascribed, in part, to the gene mutated and even the specific molecular lesion involved.<\/jats:p>","DOI":"10.1159\/000276766","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T02:50:32Z","timestamp":1265943032000},"page":"2-26","source":"Crossref","is-referenced-by-count":213,"title":["Noonan Syndrome: Clinical Aspects and Molecular 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