{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:47:29Z","timestamp":1790358449348,"version":"4.1.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; HP802-247 is a new-generation, allogeneic tissue engineering product consisting of growth-arrested, human keratinocytes (K) and fibroblasts (F) delivered in a fibrin matrix by a spray device. &lt;i&gt;Objective:&lt;\/i&gt; To identify the preferred dose of HP802-247 based on cell concentration and K\/F ratio. &lt;i&gt;Methods:&lt;\/i&gt; A multicenter, randomized, double-blind, placebo-controlled, explorative phase II study of 6 different doses of HP802-247 administered once per week for 12 consecutive weeks in chronic venous leg ulcers. &lt;i&gt;Results:&lt;\/i&gt; HP802-247 was safe and well tolerated and showed increasing efficacy dependent on cell concentration and K\/F ratio, in line with in vitro growth factor release data. The mean complete closure rate at week 12 for all patients treated with HP802-247 was 40%, and for placebo it was 33%. In contrast to placebo, all HP802-247 dose groups improved from week 12 to 24. &lt;i&gt;Conclusion:&lt;\/i&gt; As an integral part of a rational tissue engineering product development, this explorative trial identified the preferred dose of HP802-247 for further clinical studies.<\/jats:p>","DOI":"10.1159\/000277380","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T08:20:47Z","timestamp":1264494047000},"page":"114-120","source":"Crossref","is-referenced-by-count":37,"title":["Wound Stimulation by Growth-Arrested Human Keratinocytes and Fibroblasts: HP802-247, a New-Generation Allogeneic Tissue Engineering Product"],"prefix":"10.1159","volume":"220","author":[{"given":"Ren\u00e9","family":"Goedkoop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Juliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy Hou Kang","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Daroczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees-Peter","family":"de Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raf","family":"Lijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rolland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hunziker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-5214%2899%2970076-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089%2F107632704322791943"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1524-475X.2003.11403.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0906-6705.2005.00262.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1245%2Fs10434-007-9695-y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1089%2Ften.2006.12.2407"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.134.3.293"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199909023411006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1524-475X.2003.11105.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-5491.2004.01358.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000111805"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12722530"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2007.07914.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2217%2F17460751.1.5.709"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-199958050-00010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1594.2005.00138.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1743-6109.2006.00132.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/277380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/277380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:48:31Z","timestamp":1745441311000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000277380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,3,1]]},"published-print":{"date-parts":[[2010,3,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000277380","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}