{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:24:49Z","timestamp":1776122689810,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Introduction:<\/i> The aim of this study was to determine if antibiotic or anti-inflammatory medications lower serum prostate-specific antigen (PSA) in the presence or absence of inflammation in the prostatic secretions of patients with PSA levels between 2.5 and 10 ng\/ml and normal digital rectal examinations (DRE). <i>Materials and Methods:<\/i> Patients with PSA levels between 2.5 and 10 ng\/ml and normal DRE were candidates for the study. One hundred and eight patients with positive expressed prostate secretion (EPS) were randomized into antibiotics, anti-inflammatory and control groups (groups 1, 2 and 3, respectively), and 108 patients with negative EPS were randomized into similar groups (groups 4, 5 and 6, respectively). Repeat PSA levels of all patients were obtained 6 weeks after randomization and 10 core prostate biopsies were performed. <i>Results:<\/i> Median PSA levels in group 1 before and after treatment were 5.2 (4.3\u20136.4) and 4.0 ng\/ml (3.1\u20134.9), respectively (p < 0.001). The only significant decrease in PSA was observed in group 1. The percent change in PSA levels in group 1 was significantly greater than both in its control group (group 3; p < 0.001) and the EPS\u2013 antibiotics group (group 4; p < 0.001). <i>Conclusions:<\/i> Antibiotherapy significantly reduces serum PSA only in EPS+ patients, which justifies limiting the use of prebiopsy antibiotics to EPS+ patients with a normal DRE and PSA level between 2.5 and 10 ng\/ml, minimizing the major drawbacks of empirical antibiotics usage.<\/jats:p>","DOI":"10.1159\/000277596","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T07:52:38Z","timestamp":1267775558000},"page":"185-190","source":"Crossref","is-referenced-by-count":16,"title":["Impacts of Antibiotic and Anti-Inflammatory Therapies on Serum Prostate-Specific Antigen Levels in the Presence of Prostatic Inflammation: A Prospective Randomized Controlled Trial"],"prefix":"10.1159","volume":"84","author":[{"given":"Ozgur","family":"Ugurlu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Volkan","family":"Oztekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Murat","family":"Kosan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oztug","family":"Adsan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesut","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2899%2900602-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2004.10.064"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199508000-00023"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2004.04642.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fpros.2990200205"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199704000-00037"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2963959-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200011000-00021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000052500"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200204000-00032"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.pcan.4500885"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.289.20.2695"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2004.046086"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000112612"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2007.05.041"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2964572-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819911001%2968%3A7%3C1592%3A%3AAID-CNCR2820680721%3E3.0.CO%3B2-M"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2006.09.036"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000107839.06670.27"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2897%2900235-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1994.tb09180.x"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/277596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/277596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:50:05Z","timestamp":1745441405000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000277596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000277596","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}