{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:06:06Z","timestamp":1773680766702,"version":"3.50.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Conventional transbronchial needle aspiration (TBNA) is a cheap, minimally invasive tool for lung cancer staging and diagnosis. Endobronchial ultrasound-guided TBNA (EBUS-TBNA) is more sensitive but is more expensive and less widely available. We describe a prospective analysis of TBNA diagnostic, staging and cost utility in a centre in the UK. &lt;i&gt;Objectives:&lt;\/i&gt; To illustrate the potential diagnostic, staging and cost utility of a low cost conventional TBNA service. &lt;i&gt;Methods:&lt;\/i&gt; A prospective analysis of 79 TBNA procedures over a 2-year period was performed looking at performance and cost utility in a \u2018mixed\u2019 cohort with variable pre-test probability of malignancy (year 1) followed by a high probability cohort (year 2). &lt;i&gt;Results:&lt;\/i&gt; TBNA avoided mediastinoscopy in 25% of the cases overall (37% in high probability vs. 13% in the \u2018mixed\u2019 cohort, p = 0.03). The overall prevalence of malignancy was 84%, sensitivity 79%, negative predictive value 58% and accuracy 85%. Diagnostic utility varied with pre-test probability and nodal station. TBNA down-staged 8% of lung cancer patients to receive surgery and confirmed the pre-treatment stage (inoperability) in 74%. TBNA led to theoretical cost savings of GBP 560 per patient. &lt;i&gt;Conclusions:&lt;\/i&gt; TBNA can achieve a high diagnostic sensitivity for cancer in high probability patients and stage the majority appropriately, thereby avoiding unnecessary mediastinoscopies and reducing costs. It may also down-stage a minority to have surgery. TBNA is cheap, routinely available and learnable. As EBUS-TBNA will take time to develop due to its costs, all respiratory centres should perform TBNA at flexible bronchoscopy in suspected lung cancer with accessible mediastinal adenopathy.<\/jats:p>","DOI":"10.1159\/000277931","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T07:54:47Z","timestamp":1264406087000},"page":"482-489","source":"Crossref","is-referenced-by-count":33,"title":["A Prospective Study of Conventional Transbronchial Needle Aspiration: Performance and Cost Utility"],"prefix":"10.1159","volume":"79","author":[{"given":"A.R.L.","family":"Medford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Free","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.07-1362"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.125.2.527"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2005.041525"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2006.05.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000112793"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000228906"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.06-1377"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2FJTO.0b013e3181560a85"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2FLBR.0b013e318093e590"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lungcan.2005.07.013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.06-2964"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2802%2902853-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.radonc.2003.09.007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.111.1.103"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.125.2.532"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00055506"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.02.00103702"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000029312"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.124.6.2126"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejcts.2007.01.075"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jtcvs.2007.11.011"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.126.1.259"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000084050"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.07-1360"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F01243894-200605000-00010"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097%2FMCP.0b013e32832b8a45"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed%2Fhcp016"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1017%2FS0022215100108795"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/277931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/277931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:54:15Z","timestamp":1745441655000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000277931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000277931","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}