{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:26:40Z","timestamp":1762079200912,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Gonadal dysgenesis and heterosexual conditions are often associated with sex chromosome abnormalities. In this study we report on 2 cases of abnormal sex development involving numerical sex chromosome aberrations in both horse and sheep. A 17-month-old Standardbred filly was sent to an equine fertility centre as an embryo donor due to its reduced size, being much smaller than a racehorse filly of the same age, which excluded it from an athletic career. External genitalia were clinically normal but manual palpation of the reproductive tract showed the presence of a small underdeveloped uterus and ovaries, as confirmed by ultrasonographic examination. Cytogenetic investigation by CBA-banding revealed an abnormal karyotype with X chromosome monosomy (2n = 63,X). A 18-month-old ewe showed distinct heterosexual traits with presence of a vulva (with enlarged clitoris), well-developed abdominal testes and mammary glands. Internal sex adducts were atrophic as seen after mating. Cytogenetic analysis revealed the presence of XX\/XY mosaicism.<\/jats:p>","DOI":"10.1159\/000279289","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T07:53:55Z","timestamp":1267516435000},"page":"329-332","source":"Crossref","is-referenced-by-count":12,"title":["Numerical Sex Chromosome Aberrations and Abnormal Sex Development in Horse and Sheep"],"prefix":"10.1159","volume":"3","author":[{"given":"G.P.","family":"Di Meo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Neglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Perucatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Genualdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Iannuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Crocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Incarnato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Parma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Iannuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10577-009-9052-z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000118752"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1090-0233%2897%2980057-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000118751"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000118738"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186%2Fjbiol30"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03195634"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1601-5223.2001.00147.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1439-0388.2001.00274.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000118740"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2F190372a0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2746%2F042516401776254844"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.anireprosci.2004.09.008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000245911"}],"container-title":["Sexual Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:08:29Z","timestamp":1745442509000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000279289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":14,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000279289","archive":["Portico"],"relation":{},"ISSN":["1661-5425","1661-5433"],"issn-type":[{"type":"print","value":"1661-5425"},{"type":"electronic","value":"1661-5433"}],"subject":[],"published":{"date-parts":[[2009]]}}}